descSPIM: an affordable and easy-to-build light-sheet microscope optimized for tissue clearing techniques
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DOI: 10.1038/s41467-024-49131-1
Abstract: Despite widespread adoption of tissue clearing techniques in recent years, poor access to suitable light-sheet fluorescence microscopes remains a major obstacle for biomedical end-users. Here, we present descSPIM (desktop-equipped SPIM for cleared specimens), a low-cost… read more here.
Keywords: sheet; tissue clearing; light sheet; sheet microscope ... See more keywords
Depth-Varying Deconvolution of Light-Sheet Microscope Images
Sign Up to like & getrecommendations! Published in 2026 at "IEEE Photonics Technology Letters"
DOI: 10.1109/lpt.2025.3614986
Abstract: The light-sheet microscope is a powerful instrument for 3D imaging of biological samples. These samples are typically cleared using chemical methods. However, even cleared samples can still produce image blur, which increases with depth. We… read more here.
Keywords: depth varying; microscope; deconvolution; light sheet ... See more keywords
Multi-purpose SLM-light-sheet microscope
Sign Up to like & getrecommendations! Published in 2018 at "Biomedical Optics Express"
DOI: 10.1364/boe.9.005419
Abstract: By integrating a phase-only Spatial Light Modulator (SLM) into the illumination arm of a cylindrical-lens-based Selective Plane Illumination Microscope (SPIM), we have created a versatile system able to deliver high quality images by operating in… read more here.
Keywords: imaging techniques; microscope; illumination; light sheet ... See more keywords