Shelterin reduces the accessibility of telomeric overhangs
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1176
Abstract: Abstract Telomeres terminate with a 50–300 bases long single-stranded G-rich overhang, which can be misrecognized as a DNA damage repair site. Shelterin plays critical roles in maintaining and protecting telomere ends by regulating access of… read more here.
Keywords: shelterin reduces; accessibility; telomeric overhangs; accessibility telomeric ... See more keywords
Shelterin Telomere Protection Protein 1 Reduction Causes Telomere Attrition and Cellular Senescence via Sirtuin 1 Deacetylase in Chronic Obstructive Pulmonary Disease
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Respiratory Cell and Molecular Biology"
DOI: 10.1165/rcmb.2016-0198oc
Abstract: &NA; Lung cellular senescence and inflammatory response are the key events in the pathogenesis of chronic obstructive pulmonary disease (COPD) when cigarette smoke (CS) is the main etiological factor. Telomere dysfunction is induced by either… read more here.
Keywords: chronic obstructive; obstructive pulmonary; senescence; cellular senescence ... See more keywords
Shelterin Complex at Telomeres: Implications in Ageing
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Interventions in Aging"
DOI: 10.2147/cia.s256425
Abstract: Abstract Different factors influence the development and control of ageing. It is well known that progressive telomere shorting is one of the molecular mechanisms underlying ageing. The shelterin complex consists of six telomere-specific proteins which… read more here.
Keywords: ageing shelterin; complex telomeres; telomeres implications; shelterin complex ... See more keywords