Novel combination of tanshinone I and lenalidomide induces chemo-sensitivity in myeloma cells by modulating telomerase activity and expression of shelterin complex and its associated molecules
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Biology Reports"
DOI: 10.1007/s11033-018-4409-z
Abstract: Shelterin complex and its associated molecules are imperative for proper functioning and maintenance of human telomeres. These molecules in association with human telomerase have been found altered in most cancers including multiple myeloma thereby proposed… read more here.
Keywords: combination; myeloma; shelterin complex; complex associated ... See more keywords
Spatial Organization and Molecular Interactions of the Schizosaccharomyces pombe Ccq1-Tpz1-Poz1 Shelterin Complex.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2017.08.002
Abstract: The shelterin complex is a macromolecular assembly of proteins that binds to and protects telomeric DNA, which composes the ends of all linear chromosomes. Shelterin proteins prevent chromosome ends from fusing together and from eliciting… read more here.
Keywords: schizosaccharomyces pombe; shelterin complex; tpz1 poz1; ccq1 tpz1 ... See more keywords
Structural and functional analyses of the mammalian TIN2-TPP1-TRF2 telomeric complex.
Sign Up to like & getrecommendations! Published in 2017 at "Cell research"
DOI: 10.1038/cr.2017.144
Abstract: Telomeres are nucleoprotein complexes that play essential roles in protecting chromosome ends. Mammalian telomeres consist of repetitive DNA sequences bound by the shelterin complex. In this complex, the POT1-TPP1 heterodimer binds to single-stranded telomeric DNAs,… read more here.
Keywords: shelterin complex; tpp1 trf2; tin2;
Identification of Prognostic and Tumor Microenvironment by Shelterin Complex-Related Signatures in Oral Squamous Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/6849304
Abstract: Oral squamous cell carcinoma (OSCC) is a common malignant tumor of the oral cavity. Shelterin complex gene (SG) has an important role in regulating telomere structure and length. SG is considered promising as a novel… read more here.
Keywords: cell carcinoma; cell; squamous cell; shelterin complex ... See more keywords
The structural biology of the shelterin complex
Sign Up to like & getrecommendations! Published in 2019 at "Biological Chemistry"
DOI: 10.1515/hsz-2018-0368
Abstract: Abstract The shelterin complex protects telomeric DNA and plays critical roles in maintaining chromosome stability. The structures and functions of the shelterin complex have been extensively explored in the past decades. This review summarizes the… read more here.
Keywords: structural biology; biology shelterin; shelterin complex; chemistry ... See more keywords
Shelterin Complex at Telomeres: Implications in Ageing
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Interventions in Aging"
DOI: 10.2147/cia.s256425
Abstract: Abstract Different factors influence the development and control of ageing. It is well known that progressive telomere shorting is one of the molecular mechanisms underlying ageing. The shelterin complex consists of six telomere-specific proteins which… read more here.
Keywords: ageing shelterin; complex telomeres; telomeres implications; shelterin complex ... See more keywords