Transcriptomics and network pharmacology reveal the potential mechanism related to integrated stress response in the treatment of osteoporosis by Jiawei Shentong Zhuyu Decoction and verified by RT-qPCR
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DOI: 10.3389/fendo.2025.1618296
Abstract: Background Osteoporosis (OP) is a systemic skeletal disorder. The molecular mechanisms underlying the effects of Jia Wei Shentong Zhuyu Decoction (JWSTZYD) and the integrated stress response (ISR) in OP remain unclear. This study aims to… read more here.
Keywords: shentong zhuyu; treatment; pharmacology; integrated stress ... See more keywords
Shentong Zhuyu Decoction Alleviates Neuropathic Pain in Mice by Inhibiting the NMDAR-2B Receptor-Mediated CaMKII/CREB Signaling Pathway in GABAergic Neurons of the Interpeduncular Nucleus
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DOI: 10.3390/ph18101456
Abstract: Background: Shentong Zhuyu Decoction (STZYD) is a traditional Chinese medicine formula that has shown promise in alleviating neuropathic pain (NPP), yet its central mechanisms remain unclear. Methods: We investigated the STZYD effects on NPP using… read more here.
Keywords: shentong zhuyu; camkii creb; pain; pharmacology ... See more keywords