Second-harmonic generation-based methods to detect and characterize ligand-induced RNA conformational changes.
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DOI: 10.1016/j.ymeth.2019.05.012
Abstract: Second-harmonic generation (SHG) is a biophysical tool that senses ligand-induced conformational changes in biomolecules. The Biodesy Delta™ has been developed as a high-throughput screening platform to monitor conformational changes in proteins and oligonucleotides by SHG… read more here.
Keywords: harmonic generation; ligand induced; shg assay; conformational changes ... See more keywords