Molecular progression of SHH-activated medulloblastomas
Sign Up to like & getrecommendations! Published in 2019 at "Acta Neuropathologica"
DOI: 10.1007/s00401-019-02022-y
Abstract: Medulloblastoma (MB) comprises four main molecular MB subgroups (WNT, SHH, Group 3 and Group 4) with divergent biology, outcomes and subgroup-specific differences in relapses [1–6]. Metastatic recurrences are most common in Group 3 and 4… read more here.
Keywords: progression shh; shh activated; shh; dnmb ... See more keywords
Epigenetic upregulation of Schlafen11 renders WNT- and SHH- activated medulloblastomas sensitive to cisplatin.
Sign Up to like & getrecommendations! Published in 2022 at "Neuro-oncology"
DOI: 10.1093/neuonc/noac243
Abstract: BACKGROUND Intensive chemotherapeutic regimens with craniospinal irradiation have greatly improved survival in medulloblastoma patients. However, survival markedly differs among molecular subgroups and their biomarkers are unknown. Through unbiased screening, we found Schlafen family member 11… read more here.
Keywords: medulloblastoma; slfn11 expression; cisplatin; shh activated ... See more keywords
p53 Function Is Compromised by Inhibitor 2 of Phosphatase 2A in Sonic Hedgehog Medulloblastoma
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DOI: 10.1158/1541-7786.mcr-18-0485
Abstract: Medulloblastomas, the most common malignant pediatric brain tumors, have been genetically defined into four subclasses, namely WNT-activated, Sonic Hedgehog (SHH)-activated, Group 3, and Group 4. Approximately 30% of medulloblastomas have aberrant SHH signaling and thus… read more here.
Keywords: medulloblastoma; shh activated; p53; wild type ... See more keywords