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   Articles with "shh activated" as a keyword



Molecular progression of SHH-activated medulloblastomas

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recommendations! Published in 2019 at "Acta Neuropathologica"

DOI: 10.1007/s00401-019-02022-y

Abstract: Medulloblastoma (MB) comprises four main molecular MB subgroups (WNT, SHH, Group 3 and Group 4) with divergent biology, outcomes and subgroup-specific differences in relapses [1–6]. Metastatic recurrences are most common in Group 3 and 4… read more here.

Keywords: progression shh; shh activated; shh; dnmb ... See more keywords

Epigenetic upregulation of Schlafen11 renders WNT- and SHH- activated medulloblastomas sensitive to cisplatin.

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recommendations! Published in 2022 at "Neuro-oncology"

DOI: 10.1093/neuonc/noac243

Abstract: BACKGROUND Intensive chemotherapeutic regimens with craniospinal irradiation have greatly improved survival in medulloblastoma patients. However, survival markedly differs among molecular subgroups and their biomarkers are unknown. Through unbiased screening, we found Schlafen family member 11… read more here.

Keywords: medulloblastoma; slfn11 expression; cisplatin; shh activated ... See more keywords

p53 Function Is Compromised by Inhibitor 2 of Phosphatase 2A in Sonic Hedgehog Medulloblastoma

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recommendations! Published in 2018 at "Molecular Cancer Research"

DOI: 10.1158/1541-7786.mcr-18-0485

Abstract: Medulloblastomas, the most common malignant pediatric brain tumors, have been genetically defined into four subclasses, namely WNT-activated, Sonic Hedgehog (SHH)-activated, Group 3, and Group 4. Approximately 30% of medulloblastomas have aberrant SHH signaling and thus… read more here.

Keywords: medulloblastoma; shh activated; p53; wild type ... See more keywords

Molecular Subgrouping Based on Immunohistochemistry in Medulloblastoma: a Single-Center Experience.

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recommendations! Published in 2024 at "Turkish neurosurgery"

DOI: 10.5137/1019-5149.jtn.45863-23.2

Abstract: AIM Medulloblastomas (MBs) are the most commonly observed malignant brain tumors affecting children; they can be classified into molecular subgroups based on the 2016 and 2021 WHO classifications, as WNT-activated, SHH-activated and TP53-wild type, SHH-activated… read more here.

Keywords: activated tp53; shh; molecular subgroups; shh activated ... See more keywords