Intracellular Calcium Mobilization Is Required for Sonic Hedgehog Signaling.
Sign Up to like & getrecommendations! Published in 2018 at "Developmental cell"
DOI: 10.1016/j.devcel.2018.04.013
Abstract: Graded Shh signaling across fields of precursor cells coordinates patterns of gene expression, differentiation, and morphogenetic behavior as precursors form complex structures, such as the nervous system, the limbs, and craniofacial skeleton. Here we discover… read more here.
Keywords: mobilization required; intracellular calcium; calcium mobilization; shh dependent ... See more keywords
Otx2 promotes granule cell precursor proliferation and Shh-dependent medulloblastoma maintenance in vivo
Sign Up to like & getrecommendations! Published in 2018 at "Oncogenesis"
DOI: 10.1038/s41389-018-0070-6
Abstract: The developmental gene OTX2 is expressed by cerebellar granule cell precursors (GCPs), a cell population which undergoes massive expansion during the early postnatal period in response to sonic hedgehog (Shh). GCPs are thought to be… read more here.
Keywords: granule cell; otx2; proliferation; shh dependent ... See more keywords
Cell disorientation by loss of SHH-dependent mechanosensation causes cyclopia
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abn2330
Abstract: The physical causes of organ malformation remain largely unclear in most cases due to a lack of information on tissue/cell dynamics. Here, we address this issue by considering onset of cyclopia in sonic hedgehog (SHH)–inhibited… read more here.
Keywords: shh dependent; cell; shh; cell disorientation ... See more keywords