Knockdown of HIF‐1&agr; inhibits the proliferation and migration of outer root sheath cells exposed to hypoxia in vitro: An involvement of Shh pathway
Sign Up to like & getrecommendations! Published in 2017 at "Life Sciences"
DOI: 10.1016/j.lfs.2017.10.011
Abstract: Aims: Outer root sheath (ORS) is a highly proliferative component of a hair follicle. This study is performed to investigate whether hypoxia‐induced elevation of hypoxia‐inducible factor (HIF)‐1&agr;, a transcriptional activator, contributes to the outgrowth of… read more here.
Keywords: shh pathway; proliferation; ors cells; hif agr ... See more keywords
Protease nexin-1 protects against Alzheimer’s disease by regulating the sonic hedgehog signaling pathway
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Neuroscience"
DOI: 10.1080/00207454.2020.1773821
Abstract: Abstract Objective To explore the role of protease nexin-1 (PN-1) in Alzheimer’s disease (AD) via the sonic hedgehog (SHH) pathway. Methods PN-1 lentiviral activation particles were injected into APP/PS1 transgenic AD and wild-type (WT) mice;… read more here.
Keywords: alzheimer disease; ht22 cells; protease nexin; shh pathway ... See more keywords
Hedgehog pathway permissive conditions allow generation of immortal cell lines from granule cells derived from cancerous and non-cancerous cerebellum
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DOI: 10.1098/rsob.180145
Abstract: Cerebellar granule cell progenitors (GCPs) undergo proliferation in the post-natal cerebellum that is dependent on sonic hedgehog (SHH) signalling. Deregulated SHH signalling leads to type 2 medulloblastoma (MB). In this work, a novel cell culture… read more here.
Keywords: cell lines; generation immortal; cerebellum; shh pathway ... See more keywords
SHH pathway inhibition is protumourigenic in adamantinomatous craniopharyngioma
Sign Up to like & getrecommendations! Published in 2019 at "Endocrine-Related Cancer"
DOI: 10.1530/erc-18-0538
Abstract: Pharmacological inhibition of the sonic hedgehog (SHH) pathway can be beneficial against certain cancers but detrimental in others. Adamantinomatous craniopharyngioma (ACP) is a relevant pituitary tumour, affecting children and adults, that is associated with high… read more here.
Keywords: shh pathway; pathway inhibition; shh; adamantinomatous craniopharyngioma ... See more keywords
Targeting APP/AICD in Down syndrome.
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.18860
Abstract: Down syndrome (DS), a genetic disorder caused by triplication of chromosome 21, is unavoidably associated with intellectual disability due to earlyoccurring alterations of brain development. No therapies currently exist for intellectual disability in DS. Although… read more here.
Keywords: app aicd; ptch1; dentate gyrus; targeting app ... See more keywords
Old Sonic Hedgehog, new tricks: a new paradigm in thoracic malignancies
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.24411
Abstract: The Sonic Hedgehog (Shh) pathway is physiologically involved during embryogenesis, but is also activated in several diseases, including solid cancers. Previous studies have demonstrated that the Shh pathway is involved in oncogenesis, tumor progression and… read more here.
Keywords: cancer; lung cancer; sonic hedgehog; shh pathway ... See more keywords
Sonic hedgehog pathway mediates genistein inhibition of renal cancer stem cells
Sign Up to like & getrecommendations! Published in 2019 at "Oncology Letters"
DOI: 10.3892/ol.2019.10657
Abstract: Cancer stem cells (CSCs) have been implicated in the genesis, progression and recurrence of renal cancer. The sonic hedgehog (Shh) pathway serves a critical role in maintaining the stemness of CSCs. Genistein, a major isoflavone… read more here.
Keywords: shh pathway; renal cscs; cancer stem; cscs ... See more keywords