Immunohistochemical evaluation of Sonic Hedgehog signaling pathway proteins (Shh, Ptch1, Ptch2, Smo, Gli1, Gli2, and Gli3) in sporadic and syndromic odontogenic keratocysts
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Oral Investigations"
DOI: 10.1007/s00784-018-2421-2
Abstract: AimsThe aim of this study was to compare the clinical and demographic features of 62 patients presenting sporadic odontogenic keratocysts (OKCs) or OKCs associated with nevoid basal cell carcinoma syndrome (NBCCS). In conjunction with this,… read more here.
Keywords: shh ptch1; smo; ptch1 ptch2; gli1 ... See more keywords
Structural basis for catalyzed assembly of the Sonic hedgehog-Patched1 signaling complex.
Sign Up to like & getrecommendations! Published in 2022 at "Developmental cell"
DOI: 10.1016/j.devcel.2022.02.008
Abstract: The dually lipidated Sonic hedgehog (SHH) morphogen signals through the tumor suppressor membrane protein Patched1 (PTCH1) to activate the Hedgehog pathway, which is fundamental in development and cancer. SHH engagement with PTCH1 requires the GAS1… read more here.
Keywords: ptch1; patched1; shh ptch1; sonic hedgehog ... See more keywords