Hybrid Chemoenzymatic Synthesis of C7‐Sugars for Molecular Evidence of in vivo Shikimate Pathway Inhibition
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200241
Abstract: The design of distinctive chemical synthesis strategies aims for the most efficient routes towards versatile compounds in drug target studies. Here, we establish a powerful hybrid synthetic approach of total chemical and chemoenzymatic synthesis to… read more here.
Keywords: inhibition; vivo; synthesis; chemoenzymatic synthesis ... See more keywords
G6P-capturing molecules in the periplasm of Escherichia coli accelerate the shikimate pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Metabolic engineering"
DOI: 10.1016/j.ymben.2022.03.002
Abstract: Escherichia coli, the most studied prokaryote, is an excellent host for producing valuable chemicals from renewable resources as it is easy to manipulate genetically. Since the periplasmic environment can be easily controlled externally, elucidating how… read more here.
Keywords: g6p; shikimate pathway; escherichia coli; molecules periplasm ... See more keywords
4‐Hydroxybenzoic acid is a diffusible factor that connects metabolic shikimate pathway to the biosynthesis of a unique antifungal metabolite in Lysobacter enzymogenes
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Microbiology"
DOI: 10.1111/mmi.13619
Abstract: Heat‐stable antifungal factor (HSAF) produced by Lysobacter enzymogenes is a potential lead compound for developing new antibiotics. Yet, how L. enzymogenes regulates the HSAF biosynthesis remains largely unknown. Here, we show that 4‐hydroxybenzoic acid (4‐HBA)… read more here.
Keywords: biosynthesis; production; shikimate pathway; hsaf ... See more keywords
Enhanced biosynthesis of arbutin by engineering shikimate pathway in Pseudomonas chlororaphis P3
Sign Up to like & getrecommendations! Published in 2018 at "Microbial Cell Factories"
DOI: 10.1186/s12934-018-1022-8
Abstract: BackgroundArbutin is a plant-derived glycoside with potential antioxidant, antibacterial and anti-inflammatory activities. Currently, it is mainly produced by plant extraction or enzymatic processes, which suffers from expensive processing cost and low product yield. Metabolic engineering… read more here.
Keywords: engineering; chlororaphis; shikimate pathway; pathway ... See more keywords
Glyphosate excessive use chronically disrupts the shikimate pathway and can affect photosynthesis and yield in citrus trees.
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DOI: 10.2139/ssrn.4163549
Abstract: Glyphosate excessive use is reported in Brazilian citrus orchards, whereas there is speculation about its consequences and the published studies are contradictory and inconclusive. This study aimed to describe the possible harmful effects by simulating… read more here.
Keywords: glyphosate; glyphosate excessive; excessive use; citrus ... See more keywords
Uncovering the Role of PhzC as DAHP Synthase in Shikimate Pathway of Pseudomonas chlororaphis HT66
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DOI: 10.3390/biology11010086
Abstract: Simple Summary This study investigated PhzC, one essential 3-Deoxy-D-arabino-heptulosnate-7-phosphate (DAHP) synthase that catalyzes the first step of the shikimate pathway in Pseudomonas chlororaphis. We identified and characterized phzC, which is different from the reported DAHP… read more here.
Keywords: synthase; phzc; chlororaphis; dahp synthase ... See more keywords
Shikimate Kinase Plays Important Roles in Anthocyanin Synthesis in Petunia
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DOI: 10.3390/ijms232415964
Abstract: In plants, the shikimate pathway is responsible for the production of aromatic amino acids L-tryptophan, L-phenylalanine, and L-tyrosine. L-Phenylalanine is the upstream substrate of flavonoid and anthocyanin synthesis. Shikimate kinase (SK) catalyzes the phosphorylation of… read more here.
Keywords: petunia; anthocyanin synthesis; shikimate kinase; shikimate ... See more keywords
Metabolic Engineering of Shikimic Acid Biosynthesis Pathway for the Production of Shikimic Acid and Its Branched Products in Microorganisms: Advances and Prospects
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27154779
Abstract: The shikimate pathway is a necessary pathway for the synthesis of aromatic compounds. The intermediate products of the shikimate pathway and its branching pathway have promising properties in many fields, especially in the pharmaceutical industry.… read more here.
Keywords: metabolic engineering; shikimate pathway; acid; pathway ... See more keywords