Shikonin attenuates kidney tubular epithelial cells apoptosis, oxidative stress, and inflammatory response through nicotinamide adenine dinucleotide phosphate oxidase 4/PTEN pathway in acute kidney injury of sepsis model
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21936
Abstract: Natural compounds were used in the treatment of acute kidney injury (AKI) caused by sepsis. This study investigated the function of shikonin from the roots of Arnebia purpurea in sepsis‐induced AKI model. The target genes… read more here.
Keywords: sepsis; kidney injury; shikonin; phosphate ... See more keywords
Assessment of shikonin and acetyl-shikonin for mitigating quorum sensing potential of C. violaceum
Sign Up to like & getrecommendations! Published in 2021 at "Plant Growth Regulation"
DOI: 10.1007/s10725-021-00712-w
Abstract: Shikonins (SK) and acetyl-shikonins (acetyl-SK) are known to possess great pharmaceutical potentials however, their ability to disrupt infectious bacterial communication system viz. quorum sensing (QS) remains unexplored. Therefore, the rationale behind this research was to… read more here.
Keywords: quorum sensing; shikonin; violaceum; inhibition ... See more keywords
Shikonin Controls the Differentiation of CD4+CD25+ Regulatory T Cells by Inhibiting AKT/mTOR Pathway
Sign Up to like & getrecommendations! Published in 2019 at "Inflammation"
DOI: 10.1007/s10753-019-00982-7
Abstract: CD4+CD25+ regulatory T (Treg) cells maintain the function of immune tolerance and the balance of immune cells. Defects in the number and function of Treg cells can induce the development and progression of inflammatory disease.… read more here.
Keywords: treg cells; cells inhibiting; inhibiting akt; cd4 cd25 ... See more keywords
Shikonin induces necroptosis by reactive oxygen species activation in nasopharyngeal carcinoma cell line CNE-2Z
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Bioenergetics and Biomembranes"
DOI: 10.1007/s10863-017-9714-z
Abstract: Shikonin, a natural small agent, has shown inhibitory effect in many kinds of cells, which increases intracellular reactive oxygen species (ROS) level and causes mitochondrial injury. In this study, shikonin showed good inhibitory effect on… read more here.
Keywords: reactive oxygen; oxygen species; cne; shikonin ... See more keywords
Isobutyrylshikonin has a potentially stronger cytotoxic effect in oral cancer cells than its analogue shikonin in vitro.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2020.104774
Abstract: OBJECTIVES The aim of the present study was to identify the anticancer effects and the mechanisms of action of shikonin and its analogue isobutyrylshikonin in oral squamous carcinoma cells. DESIGNS The cytotoxic effects of isobutyrylshikonin… read more here.
Keywords: oral cancer; cytotoxic effect; isobutyrylshikonin shikonin; shikonin ... See more keywords
RIP1 and RIP3 contribute to shikonin-induced DNA double-strand breaks in glioma cells via increase of intracellular reactive oxygen species.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer letters"
DOI: 10.1016/j.canlet.2017.01.004
Abstract: Shikonin has been reported to induce glioma cell death via necroptosis, a type of programmed necrosis primarily mediated by RIP1 and RIP3. Although RIP1 and RIP3 are found to regulate some features of necrosis such… read more here.
Keywords: shikonin; rip1 rip3; shikonin induced; dna ... See more keywords
Shikonin alleviates allergic airway remodeling by inhibiting the ERK‐NF‐&kgr;B signaling pathway
Sign Up to like & getrecommendations! Published in 2017 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2017.05.011
Abstract: Abstract Shikonin is a naphthoquinone extracted from the root of Lithospermum erythrorhizon, and has been reported to suppress allergic airway inflammation in mice. However, the underlying mechanisms are unclear and need to be further elucidated.… read more here.
Keywords: allergic airway; alleviates allergic; shikonin alleviates; shikonin ... See more keywords
Shikonin alleviates the biotoxicity produced by pneumococcal pneumolysin
Sign Up to like & getrecommendations! Published in 2017 at "Life Sciences"
DOI: 10.1016/j.lfs.2017.04.002
Abstract: Aims: Streptococcus pneumoniae (S. pneumoniae) is a common pathogen that can cause severe infections in humans. Pneumolysin (PLY) is an important virulence trait of S. pneumoniae and has cytotoxicity, genotoxicity and pro‐inflammatory activity; it is… read more here.
Keywords: biotoxicity produced; alleviates biotoxicity; shikonin alleviates; shikonin ... See more keywords
Shikonin differentially regulates glucose metabolism via PKM2 and HIF1α to overcome apoptosis in a refractory HCC cell line.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118796
Abstract: AIMS In tumor cells, shikonin treatment has been reported to inhibit glycolysis by suppressing the activity of pyruvate kinase M2 (PKM2) and to induce apoptosis by increasing reactive oxygen species (ROS) production. However, hepatocellular carcinoma… read more here.
Keywords: hcc; glycolysis; apoptosis; metabolism ... See more keywords
Molecular identification and phytochemical screening of endophytic fungi isolated from Lithospermum officinale L. roots: A new source of shikonin.
Sign Up to like & getrecommendations! Published in 2019 at "Phytochemistry"
DOI: 10.1016/j.phytochem.2019.112116
Abstract: Endophytic fungi are microorganisms located in the inter- or intracellular compartments of plant tissues but with no harmful effects. They are considered a potential source of biological compounds. The present study was conducted to investigate… read more here.
Keywords: source; endophytic fungi; lithospermum officinale; shikonin ... See more keywords
Evaluation of the inhibition risk of shikonin on human and rat UDP-glucuronosyltransferases (UGT) through the cocktail approach.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2019.05.017
Abstract: Shikonin, a natural red colorant, is widely used for food garnishment and cosmetic ingredient in the world. Shikonin also possesses a variety of pharmacological actions, including anti-inflammation and anti-cancer activities. However, little is known about… read more here.
Keywords: glucuronosyltransferases ugt; udp glucuronosyltransferases; cocktail approach; shikonin ... See more keywords