Recent advances of antitumor shikonin/alkannin derivatives: A comprehensive overview focusing on structural classification, synthetic approaches, and mechanisms of action.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2022.114314
Abstract: Shikonin and its enantiomeric analogue, alkaninn, are prevailing natural lead compounds in the drug discovery and development of anticancer agents. Despite having numerous biological effects, the most important activity reported for shikonin derivatives is the… read more here.
Keywords: advances antitumor; recent advances; structural classification; action ... See more keywords
Shikonin derivatives as potent xanthine oxidase inhibitors: in-vitro study.
Sign Up to like & getrecommendations! Published in 2022 at "Natural product research"
DOI: 10.1080/14786419.2022.2132499
Abstract: Induction of hypersensitivity reactions (may be fatal too) by specific XO inhibitors has led to development of new molecules that are efficacious and have safer ADME profile. Among natural compounds, biologically active Alkannin/Shikonin (A/S) derivatives… read more here.
Keywords: derivatives potent; shikonin derivatives; potent xanthine; shikonin ... See more keywords
Review of Shikonin and Derivatives: Isolation, Chemistry, Biosynthesis, Pharmacology and Toxicology
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DOI: 10.3389/fphar.2022.905755
Abstract: Shikonin and its derivatives, isolated from traditional medicinal plant species of the genus Lithospermum, Alkanna, Arnebia, Anchusa, Onosma, and Echium belonging to the Boraginaceae family, have numerous applications in foods, cosmetics, and textiles. Shikonin, a… read more here.
Keywords: toxicology; review shikonin; shikonin derivatives; pharmacology ... See more keywords
Shikonin Derivatives Inhibit Inflammation Processes and Modulate MAPK Signaling in Human Healthy and Osteoarthritis Chondrocytes
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DOI: 10.3390/ijms23063396
Abstract: Osteoarthritis (OA) is the most common joint disorder and is characterized by the degeneration of articular cartilage. To develop new therapeutic approaches, we investigated the effect of shikonin derivatives on inflammation, MMP expression, and the… read more here.
Keywords: shikonin derivatives; mapk signaling; human healthy; osteoarthritis ... See more keywords
Differential relieving effects of shikonin and its derivatives on inflammation and mucosal barrier damage caused by ulcerative colitis
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DOI: 10.7717/peerj.10675
Abstract: Background Ulcerative colitis (UC) is one of the most challenging human diseases. Natural shikonin (SK) and its derivatives (with have higher accumulation) isolated from the root of Lithospermum erythrorhizon have numerous beneficial effects, such as… read more here.
Keywords: shikonin derivatives; inflammation mucosal; mucosal barrier; derivatives inflammation ... See more keywords