RIP1 and RIP3 contribute to shikonin-induced DNA double-strand breaks in glioma cells via increase of intracellular reactive oxygen species.
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DOI: 10.1016/j.canlet.2017.01.004
Abstract: Shikonin has been reported to induce glioma cell death via necroptosis, a type of programmed necrosis primarily mediated by RIP1 and RIP3. Although RIP1 and RIP3 are found to regulate some features of necrosis such… read more here.
Keywords: shikonin; rip1 rip3; shikonin induced; dna ... See more keywords
MLKL contributes to shikonin-induced glioma cell necroptosis via promotion of chromatinolysis.
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DOI: 10.1016/j.canlet.2019.09.007
Abstract: Chromatinolysis refers to enzymatic degradation of nuclear DNA and is regarded as one of the crucial events leading to cell death. Mixed-lineage kinase domain-like protein (MLKL) has been identified as a key executor of necroptosis,… read more here.
Keywords: chromatinolysis; glioma; mlkl; shikonin induced ... See more keywords