Fibroblasts derived from patients with opsismodysplasia display SHIP2‐specific cell migration and adhesion defects
Sign Up to like & getrecommendations! Published in 2017 at "Human Mutation"
DOI: 10.1002/humu.23321
Abstract: The SH2 domain containing inositol phosphatase 2 (SHIP2) dephosphorylates PI(3,4,5)P3 to generate PI(3,4)P2, a lipid involved in the control of cell migration and adhesion. The INPPL1 gene that encodes SHIP2 has been found to be… read more here.
Keywords: cell migration; adhesion; migration; migration adhesion ... See more keywords
Solution structure of SHIP2 SH2 domain and its interaction with a phosphotyrosine peptide from c-MET.
Sign Up to like & getrecommendations! Published in 2018 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2018.08.012
Abstract: SH2 domain-containing inositol 5-phosphatase 2 (SHIP2) binds with the Y1356-phosphorylated hepatocyte growth factor (HGF) receptor, c-MET, through its SH2 domain, which is essential for the role of SHIP2 in HGF-induced cell scattering and cell spreading.… read more here.
Keywords: sh2; ship2 sh2; structure; sh2 domain ... See more keywords
232 Endothelial ship2 knockout causes nox2 nadph oxidase-dependent oxidative stress and endothelial dysfunction
Sign Up to like & getrecommendations! Published in 2017 at "Heart"
DOI: 10.1136/heartjnl-2017-311726.230
Abstract: Introduction Insulin-resistant type 2 diabetes mellitus (DM) leads to premature death and disability, primarily as a consequence of accelerated vascular disease. Shc homology 2-containing inositol 5 phosphatase-2 (SHIP2) is a lipid phosphatase that suppresses insulin… read more here.
Keywords: reduction; dependent oxidative; oxidative stress; ship2 ... See more keywords
SHIP2–PLK1 crosstalk promotes sensitivity to dual inhibition in esophageal squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Cancer"
DOI: 10.1186/s12943-025-02454-z
Abstract: Drug synergy in cancer therapy has gained attention for its potential to enhance efficacy and minimize adverse effects. Synergy, where the combined effect of drugs exceeds the sum of their individual effects, is beneficial in… read more here.
Keywords: esophageal squamous; inhibition; cell; squamous cell ... See more keywords
Inhibition of SHIP2 activity inhibits cell migration and could prevent metastasis in breast cancer cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cell Science"
DOI: 10.1242/jcs.216408
Abstract: ABSTRACT Metastasis of breast cancer cells to distant organs is responsible for ∼50% of breast cancer-related deaths in women worldwide. SHIP2 (also known as INPPL1) is a phosphoinositide 5-phosphatase for phosphatidylinositol (3,4,5)-trisphosphate [PI(3,4,5)P3] and phosphatidylinositol… read more here.
Keywords: migration; ship2; cancer cells; breast cancer ... See more keywords
Structural Insights into the Binding Propensity of Human SHIP2 SH2 to Oncogenic CagA Isoforms from Helicobacter pylori
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231911299
Abstract: SHIP2 is a multi-domain inositol 5-phosphatase binding to a variety of phosphotyrosine (pY)-containing proteins through its SH2 domain, so as to regulate various cell signaling pathways by modulating the phosphatidylinositol level in the plasma membrane.… read more here.
Keywords: structural insights; caga; ship2; ship2 sh2 ... See more keywords
Cancer-Related Mutations in the Sam Domains of EphA2 Receptor and Ship2 Lipid Phosphatase: A Computational Study
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DOI: 10.3390/molecules29051024
Abstract: The lipid phosphatase Ship2 interacts with the EphA2 receptor by forming a heterotypic Sam (sterile alpha motif)–Sam complex. Ship2 works as a negative regulator of receptor endocytosis and consequent degradation, and anti-oncogenic effects in cancer… read more here.
Keywords: cancer; sam; epha2 receptor; ship2 ... See more keywords
Ebselen enhances insulin sensitivity and decreases oxidative stress by inhibiting SHIP2 and protects from inflammation in diabetic mice
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.66314
Abstract: Ebselen, a multifunctional organoselenium compound, has been recognized as a potential treatment for diabetes-related disorders. However, the underlying mechanisms whereby ebselen regulates metabolic pathways remain elusive. We discovered that ebselen inhibits lipid phosphatase SHIP2 (Src… read more here.
Keywords: ebselen; diabetic mice; ship2; insulin sensitivity ... See more keywords