Fibroblasts derived from patients with opsismodysplasia display SHIP2‐specific cell migration and adhesion defects
Sign Up to like & getrecommendations! Published in 2017 at "Human Mutation"
DOI: 10.1002/humu.23321
Abstract: The SH2 domain containing inositol phosphatase 2 (SHIP2) dephosphorylates PI(3,4,5)P3 to generate PI(3,4)P2, a lipid involved in the control of cell migration and adhesion. The INPPL1 gene that encodes SHIP2 has been found to be… read more here.
Keywords: cell migration; adhesion; migration; migration adhesion ... See more keywords
Solution structure of SHIP2 SH2 domain and its interaction with a phosphotyrosine peptide from c-MET.
Sign Up to like & getrecommendations! Published in 2018 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2018.08.012
Abstract: SH2 domain-containing inositol 5-phosphatase 2 (SHIP2) binds with the Y1356-phosphorylated hepatocyte growth factor (HGF) receptor, c-MET, through its SH2 domain, which is essential for the role of SHIP2 in HGF-induced cell scattering and cell spreading.… read more here.
Keywords: sh2; ship2 sh2; structure; sh2 domain ... See more keywords
232 Endothelial ship2 knockout causes nox2 nadph oxidase-dependent oxidative stress and endothelial dysfunction
Sign Up to like & getrecommendations! Published in 2017 at "Heart"
DOI: 10.1136/heartjnl-2017-311726.230
Abstract: Introduction Insulin-resistant type 2 diabetes mellitus (DM) leads to premature death and disability, primarily as a consequence of accelerated vascular disease. Shc homology 2-containing inositol 5 phosphatase-2 (SHIP2) is a lipid phosphatase that suppresses insulin… read more here.
Keywords: reduction; dependent oxidative; oxidative stress; ship2 ... See more keywords
Inhibition of SHIP2 activity inhibits cell migration and could prevent metastasis in breast cancer cells
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DOI: 10.1242/jcs.216408
Abstract: ABSTRACT Metastasis of breast cancer cells to distant organs is responsible for ∼50% of breast cancer-related deaths in women worldwide. SHIP2 (also known as INPPL1) is a phosphoinositide 5-phosphatase for phosphatidylinositol (3,4,5)-trisphosphate [PI(3,4,5)P3] and phosphatidylinositol… read more here.
Keywords: migration; ship2; cancer cells; breast cancer ... See more keywords
Structural Insights into the Binding Propensity of Human SHIP2 SH2 to Oncogenic CagA Isoforms from Helicobacter pylori
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DOI: 10.3390/ijms231911299
Abstract: SHIP2 is a multi-domain inositol 5-phosphatase binding to a variety of phosphotyrosine (pY)-containing proteins through its SH2 domain, so as to regulate various cell signaling pathways by modulating the phosphatidylinositol level in the plasma membrane.… read more here.
Keywords: structural insights; caga; ship2; ship2 sh2 ... See more keywords
Ebselen enhances insulin sensitivity and decreases oxidative stress by inhibiting SHIP2 and protects from inflammation in diabetic mice
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.66314
Abstract: Ebselen, a multifunctional organoselenium compound, has been recognized as a potential treatment for diabetes-related disorders. However, the underlying mechanisms whereby ebselen regulates metabolic pathways remain elusive. We discovered that ebselen inhibits lipid phosphatase SHIP2 (Src… read more here.
Keywords: ebselen; diabetic mice; ship2; insulin sensitivity ... See more keywords