CTL-mediated immunotherapy can suppress SHIV rebound in ART-free macaques
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09725-6
Abstract: A major barrier to human immunodeficiency virus (HIV) cure is the existence of viral reservoirs that lead to viral rebound following discontinuation of antiretroviral therapy (ART). We postulate that enhancing cytotoxic T lymphocytes (CTL) targeting… read more here.
Keywords: viral rebound; rebound art; art free; shiv ... See more keywords
Long-term protective immunity induced by an adjuvant-containing live-attenuated AIDS virus
Sign Up to like & getrecommendations! Published in 2021 at "npj Vaccines"
DOI: 10.1038/s41541-021-00386-5
Abstract: The use of an adjuvant in vaccination is thought to be effective for enhancing immune responses to various pathogens. We genetically constructed a live attenuated simian human immunodeficiency virus (SHIV) to express the adjuvant molecule… read more here.
Keywords: live attenuated; aids virus; shiv ag85b; shiv ... See more keywords
Antibody and TLR7 Agonist Delay Viral Rebound in SHIV-Infected Monkeys
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DOI: 10.1038/s41586-018-0600-6
Abstract: The latent viral reservoir is the critical barrier for the development of a cure for HIV-1 infection. Previous studies have shown direct antiviral activity of potent HIV-1 Env-specific broadly neutralizing antibodies (bNAbs) administered when antiretroviral therapy… read more here.
Keywords: viral reservoir; rebound; antibody; viral rebound ... See more keywords
Protection against a mixed SHIV challenge by a broadly neutralizing antibody cocktail
Sign Up to like & getrecommendations! Published in 2017 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aao4235
Abstract: A combination of HIV-1–specific broadly neutralizing antibodies is necessary to protect rhesus monkeys against a mixed SHIV challenge. Swatting away a swarm Monoclonal antibodies are being tested as therapy for many infections, including HIV. However,… read more here.
Keywords: mixed shiv; challenge; shiv challenge; antibody ... See more keywords
Differential Outcomes following Optimization of Simian-Human Immunodeficiency Viruses from Clades AE, B, and C
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DOI: 10.1128/jvi.01860-19
Abstract: We sought to enhance the infectivity of three SHIV stocks by optimization of a key residue in human immunodeficiency virus type 1 (HIV-1) Env (Env375). We developed the following three new simian-human immunodeficiency virus (SHIV)… read more here.
Keywords: immunodeficiency virus; virus; shiv 325ch; shiv ... See more keywords
Novel Strategy To Adapt Simian-Human Immunodeficiency Virus E1 Carrying env from an RV144 Volunteer to Rhesus Macaques: Coreceptor Switch and Final Recovery of a Pathogenic Virus with Exclusive R5 Tropism
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Virology"
DOI: 10.1128/jvi.02222-17
Abstract: Understanding the protective principles that lead to a safe, effective vaccine against HIV in nonhuman primate (NHP) models requires test viruses that allow the evaluation of anti-HIV envelope responses. Reduced HIV acquisition risk in RV144… read more here.
Keywords: rhesus; hiv; rv144; shiv e1p5 ... See more keywords
Cooperation Between Systemic and Mucosal Antibodies Induced by Virosomal Vaccines Targeting HIV-1 Env: Protection of Indian Rhesus Macaques Against Low-Dose Intravaginal SHIV Challenges
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.788619
Abstract: A virosomal vaccine inducing systemic/mucosal anti-HIV-1 gp41 IgG/IgA had previously protected Chinese-origin rhesus macaques (RMs) against vaginal SHIVSF162P3 challenges. Here, we assessed its efficacy in Indian-origin RMs by intramuscular priming/intranasal boosting (n=12/group). Group K received… read more here.
Keywords: shiv; systemic mucosal; protection; hiv ... See more keywords
Circulating Plasma Exosomal Proteins of Either SHIV-Infected Rhesus Macaque or HIV-Infected Patient Indicates a Link to Neuropathogenesis
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DOI: 10.3390/v15030794
Abstract: Despite the suppression of human immunodeficiency virus (HIV) replication by combined antiretroviral therapy (cART), 50–60% of HIV-infected patients suffer from HIV-associated neurocognitive disorders (HAND). Studies are uncovering the role of extracellular vesicles (EVs), especially exosomes,… read more here.
Keywords: shiv infected; shiv; circulating plasma; exo ... See more keywords