A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation
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DOI: 10.1186/s12974-017-0906-6
Abstract: BackgroundKv1.3 potassium channels regulate microglial functions and are overexpressed in neuroinflammatory diseases. Kv1.3 blockade may selectively inhibit pro-inflammatory microglia in neurological diseases but the molecular and cellular mechanisms regulated by Kv1.3 channels are poorly defined.MethodsWe… read more here.
Keywords: kv1; lps induced; pharmacology; shk 223 ... See more keywords