Mitochondrial serine hydroxymethyltransferase 2 is a potential diagnostic and prognostic biomarker for human glioma
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Neurology and Neurosurgery"
DOI: 10.1016/j.clineuro.2017.01.005
Abstract: OBJECTIVE Scholars have gradually come to appreciate the relevance of serine and glycine metabolism. Recently, researchers have discovered that mitochondrial serine hydroxymethyltransferase 2 (SHMT2) is overexpressed in various types of cancer. However, the function of… read more here.
Keywords: expression shmt2; mitochondrial serine; glioma; shmt2 ... See more keywords
Downregulation of SHMT2 promotes the prostate cancer proliferation and metastasis by inducing epithelial-mesenchymal transition.
Sign Up to like & getrecommendations! Published in 2022 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2022.113138
Abstract: Serine hydroxymethyltransferase 2 (SHMT2) is a key enzyme that regulates serine/glycine transition; however, its specific function and molecular mechanisms in tumors remain controversial. In this study, we aimed to enhance the understanding in this regard.… read more here.
Keywords: cancer; prostate cancer; proliferation; transition ... See more keywords
Serine hydroxymethyltransferase 2 (SHMT2) potentiates the aggressive process of oral squamous cell carcinoma by binding to interleukin enhancer-binding factor 2 (ILF2)
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2051886
Abstract: ABSTRACT Oral squamous cell carcinoma (OSCC) is a frequent threatening head and neck malignancy. Serine hydroxymethyltransferase 2 (SHMT2) was identified to be upregulated in OSCC and its high expression was associated with poor patient prognosis.… read more here.
Keywords: cell; ilf2; shmt2; squamous cell ... See more keywords
Inhibition of SHMT2 mRNA translation increases embryonic mortality in sheep
Sign Up to like & getrecommendations! Published in 2022 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioac152
Abstract: Abstract The one-carbon metabolism (OCM) pathway provides purines and thymidine for synthesis of nucleic acids required for cell division, and S-adenosyl methionine for polyamine and creatine syntheses and the epigenetic regulation of gene expression. This… read more here.
Keywords: mao shmt2; shmt2 mrna; shmt2; inhibition shmt2 ... See more keywords
Exosome-mediated transfer of circ_0063526 enhances cisplatin resistance in gastric cancer cells via regulating miR-449a/SHMT2 axis
Sign Up to like & getrecommendations! Published in 2022 at "Anti-Cancer Drugs"
DOI: 10.1097/cad.0000000000001386
Abstract: Exosomes are critical mediators of intercellular communication. Exosomal circular RNAs (circRNAs) have been reported to play critical roles in the development of chemoresistance in various tumors, including gastric cancer. However, the role of exosomal circ_0063526… read more here.
Keywords: shmt2; resistance; circ 0063526; gastric cancer ... See more keywords
Highlights from the literature
Sign Up to like & getrecommendations! Published in 2022 at "Archives of Disease in Childhood"
DOI: 10.1136/archdischild-2022-324260
Abstract: To sustain rapid tumor growth, glioma cells must have the ability to adapt in order to survive in their rapidly changing and often harsh microenvironment. A recent study in the journal Nature elegantly describes a… read more here.
Keywords: glioblastoma cells; shmt2; glycine; glioma cells ... See more keywords
Silencing SHMT2 inhibits the progression of tongue squamous cell carcinoma through cell cycle regulation
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Cell International"
DOI: 10.1186/s12935-021-01880-5
Abstract: Background Serine hydroxymethyltransferase 2 (SHMT2) is a vital metabolic enzyme in one carbon metabolism catalyzing the conversion of serine to glycine, which has been reported to play a crucial role in the progression of tumors.… read more here.
Keywords: tscc; cell cycle; shmt2; expression ... See more keywords
Knockdown of SHMT2 enhances the sensitivity of gastric cancer cells to radiotherapy through the Wnt/β-catenin pathway
Sign Up to like & getrecommendations! Published in 2022 at "Open Life Sciences"
DOI: 10.1515/biol-2022-0480
Abstract: Abstract Gastric cancer (GC) is one of the most common malignant tumors. The mechanism of GC radioresistance and new radiosensitizers must be revealed and developed to treat GC. Serine hydroxymethyltransferase 2 (SHMT2) is responsible for… read more here.
Keywords: radiotherapy wnt; shmt2; wnt catenin; gastric cancer ... See more keywords
High expression of SHMT2 is correlated with tumor progression and predicts poor prognosis in gastrointestinal tumors.
Sign Up to like & getrecommendations! Published in 2019 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_201911_19431
Abstract: OBJECTIVE Gastrointestinal tumors are malignant tumors with high morbidity. Mitochondrial serine hydroxymethyltransferase 2 (SHMT2) is a key enzyme in the synthesis of serine and glycine, which has prognostic and therapeutic value for many malignant tumors. However, the… read more here.
Keywords: gastrointestinal tumors; shmt2 expression; shmt2; expression ... See more keywords
Increased Expression of SHMT2 Is Associated With Poor Prognosis and Advanced Pathological Grade in Oral Squamous Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.588530
Abstract: This study focused on the expression of mitochondrial serine hydroxymethyltransferase (SHMT2) in oral squamous cell carcinoma (OSCC) and its correlation with clinical traits and the prognosis of OSCC patients. Immunochemical staining and Western blotting were… read more here.
Keywords: oral squamous; prognosis; squamous cell; shmt2 ... See more keywords
Metformin Is a Pyridoxal-5′-phosphate (PLP)-Competitive Inhibitor of SHMT2
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13164009
Abstract: Simple Summary The mitochondrial enzyme serine hydroxymethyltransferase (SHMT2), which converts serine into glycine and generates 1C units for cell growth, is one of the most consistently overexpressed metabolic enzymes in cancer. Here, we reveal that… read more here.
Keywords: inhibitor; plp competitive; metformin; shmt2 ... See more keywords