Articles with "shmt2 inhibitors" as a keyword



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Study of SHMT2 Inhibitors and Their Binding Mechanism by Computational Alanine Scanning

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Published in 2019 at "Journal of chemical information and modeling"

DOI: 10.1021/acs.jcim.9b00370

Abstract: Mitochondrial serine hydroxymethyl transferase isoform 2 (SHMT2) has attracted increasing attention as a pivotal catalyzing regulator of the serine/glycine pathway in the one-carbon metabolism of cancer cells. However, few inhibitors that target this potential anticancer… read more here.

Keywords: binding mechanism; study shmt2; alanine scanning; shmt2 inhibitors ... See more keywords