6‐Shogaol Reduces Renal Macrophage Infiltration by Targeting the STING Pathway to Alleviate Cisplatin Induced Renal Injury
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DOI: 10.1002/ptr.70053
Abstract: Cisplatin is a widely used chemotherapeutic agent, but its dose‐limiting nephrotoxicity remains a major clinical challenge. 6‐Shogaol, a bioactive compound with potent anti‐inflammatory and antioxidant properties, exhibits strong binding affinity for STING—a key mediator in… read more here.
Keywords: cisplatin; macrophage infiltration; injury; shogaol ... See more keywords
6-Shogaol from ginger shows anti-tumor effect in cervical carcinoma via PI3K/Akt/mTOR pathway
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DOI: 10.1007/s00394-020-02440-9
Abstract: 6-Shogaol, an active phenolic compound from ginger (Zingiber officinale), can inhibit the growth of a variety of human cancer cells. Nevertheless, its underlying molecular mechanisms in cervical cancer remain unclear. In this study, we systematically… read more here.
Keywords: apoptosis; pi3k akt; akt mtor; cell ... See more keywords
Shogaol but not gingerol has a neuroprotective effect on hemorrhagic brain injury: Contribution of the &agr;, &bgr;‐unsaturated carbonyl to heme oxygenase‐1 expression
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.10.029
Abstract: Abstract We investigated the effects of shogaol, which has an &agr;, &bgr;‐unsaturated carbonyl group, and gingerol, which does not, on primary‐cultured microglia to understand how the &agr;, &bgr;‐unsaturated carbonyl interacts with Kelch‐like ECH‐associated protein (Keap)1.… read more here.
Keywords: agr bgr; heme oxygenase; bgr unsaturated; unsaturated carbonyl ... See more keywords
From Kitchen Spice to Neuroprotector: The Role of 6-Shogaol in Parkinson's Disease Management.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.5c09022
Abstract: 6-Shogaol (6S), the major bioactive component of ginger, exhibits diverse pharmacological properties. This study investigated the therapeutic potential of 6S against α-synuclein (α-Syn), a key pathological marker in Parkinson's disease (PD), using an in vivo… read more here.
Keywords: disease; spice neuroprotector; kitchen spice; shogaol ... See more keywords
Oral Delivery of Nanoparticles Loaded With Ginger Active Compound, 6-Shogaol, Attenuates Ulcerative Colitis and Promotes Wound Healing in a Murine Model of Ulcerative Colitis
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DOI: 10.1093/ecco-jcc/jjx115
Abstract: Background and Aims Oral drug delivery is the most attractive pathway for ulcerative colitis [UC] therapy, since it has many advantages. However, this strategy has encountered many challenges, including the instability of drugs in the… read more here.
Keywords: nanoparticles loaded; delivery; colitis; ulcerative colitis ... See more keywords
6-shogaol against 3-Nitropropionic acid-induced Huntington’s disease in rodents: Based on molecular docking/targeting pro-inflammatory cytokines/NF-κB-BDNF-Nrf2 pathway
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DOI: 10.1371/journal.pone.0305358
Abstract: Background Huntington’s disease (HD) is an extremely harmful autosomal inherited neurodegenerative disease. Motor dysfunction, mental disorder, and cognitive deficits are the characteristic features of this disease. The current study examined whether 6-shogaol has a protective… read more here.
Keywords: nitropropionic acid; huntington disease; factor; acid ... See more keywords
Ginger Constituent 6-Shogaol Inhibits Inflammation- and Angiogenesis-Related Cell Functions in Primary Human Endothelial Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.844767
Abstract: Rhizomes from Zingiber officinale Roscoe are traditionally used for the treatment of a plethora of pathophysiological conditions such as diarrhea, nausea, or rheumatoid arthritis. While 6-gingerol is the pungent principle in fresh ginger, in dried… read more here.
Keywords: angiogenesis related; endothelial cells; shogaol; cell functions ... See more keywords
Synthesis of New Shogaol Analogues as NRF2 Activators and Evaluation of Their Anti-Inflammatory Activity, Modes of Action and Metabolic Stability
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DOI: 10.3390/antiox12020475
Abstract: 6-shogaol is a natural and the most potent bioactive vanilloid in dried Zingiber officinale rhizomes. Many scientific studies have reported the diverse biological activities of 6-shogaol. However, the major drawback of 6-shogaol is its instability… read more here.
Keywords: stcs; anti inflammatory; shogaol; activity ... See more keywords
[6]-Shogaol Attenuates Oxaliplatin-Induced Allodynia through Serotonergic Receptors and GABA in the Spinal Cord in Mice
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DOI: 10.3390/ph15060726
Abstract: Although oxaliplatin is a well-known anti-cancer agent used for the treatment of colorectal cancer, treated patients often experience acute cold and mechanical allodynia as side effects. Unfortunately, no optimal treatment has been developed yet. In… read more here.
Keywords: injection; allodynia; shogaol; cold mechanical ... See more keywords
6-Shogaol Abrogates Parkinson’s Disease in Rotenone-Induced Rodents: Based on In Silico Study and Inhibiting TNF-α/NF-κB/IL-1β/MAO-B
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DOI: 10.3390/ph17101348
Abstract: Background/Objectives: 6-Shogaol is a comparatively innovative anti-Parkinson’s remedy with antioxidant and anti-inflammatory characteristics. This investigation intended to determine the role of 6-shogaol in the Parkinson’s disease (PD) paradigm in rotenone-induced rats. Methods: Thirty male Wistar… read more here.
Keywords: shogaol; mao; rotenone induced; parkinson disease ... See more keywords
Enhanced Oral Bioavailability, Anti-Tumor Activity and Hepatoprotective Effect of 6-Shogaol Loaded in a Type of Novel Micelles of Polyethylene Glycol and Linoleic Acid Conjugate
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DOI: 10.3390/pharmaceutics11030107
Abstract: 6-shogaol is a promising anti-cancer and anti-inflammatory agent. However, the treatment effectiveness of 6-shogaol is limited by poor water solubility, poor oral absorption and rapid metabolism. Herein, 6-shogaol loaded in micelles (SMs) were designed to… read more here.
Keywords: oral bioavailability; bioavailability; effect; linoleic acid ... See more keywords