Enhanced antiviral and antifibrotic effects of short hairpin RNAs targeting HBV and TGF-β in HBV-persistent mice
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-04170-1
Abstract: The hepatitis B virus (HBV) causes acute and chronic liver infection, which may lead to liver cirrhosis and hepatocellular carcinoma. Current treatments including interferons and nucleotide analogs, have limited therapeutic effects, underscoring the need to… read more here.
Keywords: hbv persistent; hbv; tgf; persistent mice ... See more keywords
Inhibition of posterior capsule opacification by adenovirus-mediated delivery of short hairpin RNAs targeting TERT in a rabbit model.
Sign Up to like & getrecommendations! Published in 2023 at "Current eye research"
DOI: 10.1080/02713683.2023.2194587
Abstract: PURPOSE Posterior capsule opacification (PCO) is the most common postoperative complication after cataract surgery and cannot yet be eliminated. Here, we investigated the inhibitory effects of telomerase reverse transcriptase (TERT) gene silencing on PCO in… read more here.
Keywords: capsule opacification; posterior capsule; hairpin rnas; rabbit model ... See more keywords
IGFBP5 antisense and short hairpin RNA (shRNA) constructs improve erectile function by inducing cavernosum angiogenesis in diabetic mice
Sign Up to like & getrecommendations! Published in 2022 at "Andrology"
DOI: 10.1111/andr.13234
Abstract: The incidence of diabetic erectile dysfunction (ED) is rapidly increasing, and due to the severe angiopathy caused by diabetes, current drugs are ineffective at treating ED. Insulin‐like growth factor‐binding protein 5 (IGFBP5) promotes cell death… read more here.
Keywords: hairpin rna; short hairpin; igfbp5 antisense; antisense short ... See more keywords
Influenza A Virus Production in Mouse Lung Is Inhibited by Inhalation of Aerosol Polyethylenimine/Short Hairpin RNA Plasmid Complexes
Sign Up to like & getrecommendations! Published in 2022 at "Disease Markers"
DOI: 10.1155/2022/7404813
Abstract: Influenza pandemics are a global threat to human health, with existing vaccines and antiviral drugs providing limited protection. There is an urgent need for new prophylactic and treatment strategies. In this study, 12 short hairpin… read more here.
Keywords: aerosol; production; plkd 391; short hairpin ... See more keywords
Short Hairpin RNAs for Strand-Specific Small Interfering RNA Production
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2020.00940
Abstract: RNA interference (RNAi) is an effective mechanism for inhibiting gene expression at the post-transcriptional level. Expression of a messenger RNA (mRNA) can be inhibited by a ∼22-nucleotide (nt) small interfering (si)RNA with the corresponding reverse… read more here.
Keywords: small interfering; rna; hairpin; strand ... See more keywords
Enhanced Antiviral Ability by a Combination of Zidovudine and Short Hairpin RNA Targeting Avian Leukosis Virus
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2021.808982
Abstract: Avian leukosis virus (ALV) causes tumor diseases in poultry and is circulating all over the world, leading to significant economic losses. In addition, mixed infection of ALV with other viruses is very common and is… read more here.
Keywords: combination; leukosis virus; hairpin rna; avian leukosis ... See more keywords
Evaluation of the Elements of Short Hairpin RNAs in Developing shRNA-Containing CAR T Cells
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15102848
Abstract: Simple Summary Knocking down genes by shRNAs in CAR T cells offers the potential of expanding the therapy’s efficacy beyond its initial success. Since shRNAs are in the CAR construct, only the CAR specifically will… read more here.
Keywords: car; shrna containing; short hairpin; containing car ... See more keywords
Multi-resistance strategy for viral diseases and in vitro short hairpin RNA verification method in pigs
Sign Up to like & getrecommendations! Published in 2018 at "Asian-Australasian Journal of Animal Sciences"
DOI: 10.5713/ajas.17.0749
Abstract: Objective Foot and mouth disease (FMD) and porcine reproductive and respiratory syndrome (PRRS) are major diseases that interrupt porcine production. Because they are viral diseases, vaccinations are of only limited effectiveness in preventing outbreaks. To… read more here.
Keywords: strategy; verification method; short hairpin; viral diseases ... See more keywords