Screening Intrinsically Disordered Regions for Short Linear Binding Motifs.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0524-0_27
Abstract: The intrinsically disordered regions of the proteome are enriched in short linear motifs (SLiMs) that serve as binding sites for peptide binding proteins. These interactions are often of low-to-mid micromolar affinities and are challenging to… read more here.
Keywords: screening intrinsically; disordered regions; regions short; short linear ... See more keywords
Profiling the short, linear, non-disulfide bond-containing peptidome from the venom of the scorpion Tityus obscurus.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of proteomics"
DOI: 10.1016/j.jprot.2017.09.006
Abstract: Many scorpion accidents occur in the Brazilian Amazonian region and are frequently caused by Tityus obscurus. Approximately 5% of the crude venom of this species is composed of short linear, non-disulfide-bridged peptides, which have not… read more here.
Keywords: venom; linear non; scorpion; non disulfide ... See more keywords
Elucidation of Short Linear Motif-Based Interactions of the FERM Domains of Ezrin, Radixin, Moesin, and Merlin.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemistry"
DOI: 10.1021/acs.biochem.3c00096
Abstract: The ERM (ezrin, radixin, and moesin) family of proteins and the related protein merlin participate in scaffolding and signaling events at the cell cortex. The proteins share an N-terminal FERM [band four-point-one (4.1) ERM] domain… read more here.
Keywords: motif based; short linear; radixin moesin; ezrin radixin ... See more keywords
SLiMAn: An Integrative Web Server for Exploring Short Linear Motif-Mediated Interactions in Interactomes.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.1c00964
Abstract: Cells express thousands of macromolecules, and their functioning relies on multiple networks of intermolecular interactions. These interactions can be experimentally determined at different spatial and temporal resolutions. But, physical interfaces are not often delineated directly,… read more here.
Keywords: web server; linear motif; short linear;
A short linear motif in scaffold Nup145C connects Y-complex with pre-assembled outer ring Nup82 complex
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01160-9
Abstract: Nucleocytoplasmic transport occurs through nuclear pore complexes (NPCs), which are formed from multiple copies of ~30 different nucleoporins (Nups) and inserted into the double nuclear membrane. Many of these Nups are organized into subcomplexes, of… read more here.
Keywords: short linear; nup82 complex; pre assembled; linear motif ... See more keywords
Orchestrating serine/threonine phosphorylation and elucidating downstream effects by short linear motifs
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Journal"
DOI: 10.1042/bcj20200714
Abstract: Cellular function is based on protein–protein interactions. A large proportion of these interactions involves the binding of short linear motifs (SLiMs) by folded globular domains. These interactions are regulated by post-translational modifications, such as phosphorylation,… read more here.
Keywords: linear motifs; short linear; phosphorylation; serine threonine ... See more keywords
Characterization of Cationic Modified Short Linear Glucan and Fabrication of Complex Nanoparticles with Low and High Methoxy Pectin
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DOI: 10.3390/foods10102509
Abstract: In this study, we chemically modified the short linear glucan (SLG) using the 3-chloro-2-hydroxypropyl trimethylammonium chloride to introduce a positive surface charge via cationization (CSLG). We then prepared CSLG-based binary nanocomplex particles through electrostatic interactions… read more here.
Keywords: modified short; linear glucan; low high; complex nanoparticles ... See more keywords
Computational Analysis of Short Linear Motifs in the Spike Protein of SARS-CoV-2 Variants Provides Possible Clues into the Immune Hijack and Evasion Mechanisms of Omicron Variant
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23158822
Abstract: Short linear motifs (SLiMs) are short linear sequences that can mediate protein–protein interaction. Mimicking eukaryotic SLiMs to compete with extra- or intracellular binding partners, or to sequester host proteins is the crucial strategy of viruses… read more here.
Keywords: cov variants; omicron variant; short linear; linear motifs ... See more keywords
Spider Neurotoxins, Short Linear Cationic Peptides and Venom Protein Classification Improved by an Automated Competition between Exhaustive Profile HMM Classifiers
Sign Up to like & getrecommendations! Published in 2017 at "Toxins"
DOI: 10.3390/toxins9080245
Abstract: Spider venoms are rich cocktails of bioactive peptides, proteins, and enzymes that are being intensively investigated over the years. In order to provide a better comprehension of that richness, we propose a three-level family classification… read more here.
Keywords: spider neurotoxins; spider; classification; neurotoxins short ... See more keywords