Combined Lung and Liver Transplantation for Short Telomere Syndrome
Sign Up to like & getrecommendations! Published in 2020 at "Liver Transplantation"
DOI: 10.1002/lt.25734
Abstract: Telomeres are DNA-protein structures located at the chromosome ends and terminating with an essential single-stranded 3'-overhang.1 Their role is to maintain genomic integrity by protecting chromosomes from degradation and illegitimate recombination. Telomeres progressively shorten during… read more here.
Keywords: transplantation short; combined lung; transplantation; liver transplantation ... See more keywords
Clinical Correlates and Treatment Outcomes for Patients With Short Telomere Syndromes
Sign Up to like & getrecommendations! Published in 2018 at "Mayo Clinic Proceedings"
DOI: 10.1016/j.mayocp.2018.05.015
Abstract: Abstract Short telomere syndromes (STSs) are accelerated aging syndromes with multisystemic manifestations that present complex management challenges. In this article, we discuss a single‐institution experience in diagnosing and managing patients with inherited STSs. In total,… read more here.
Keywords: telomere syndromes; correlates treatment; clinical correlates; short telomere ... See more keywords
Highly atypical myeloblasts in acute myeloid leukaemia with myelodysplasia‐related changes in a patient with short telomere syndrome
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Haematology"
DOI: 10.1111/bjh.15505
Abstract: A 58-year-old man with a history of short telomere syndrome developed interstitial pulmonary fibrosis and underwent bilateral lung transplantation 20 months prior to presenting with fever and night sweats. He was found to have a… read more here.
Keywords: highly atypical; myeloid leukaemia; telomere syndrome; short telomere ... See more keywords
Short telomere syndromes cause a primary T cell immunodeficiency
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Investigation"
DOI: 10.1172/jci120216
Abstract: The mechanisms that drive T cell aging are not understood. We report that children and adult telomerase mutation carriers with short telomere length (TL) develop a T cell immunodeficiency that can manifest in the absence… read more here.
Keywords: mutation carriers; apoptosis; cell immunodeficiency; short telomere ... See more keywords
Liver Histology in Short Telomere Syndrome: A Case Report and Review of the Literature.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of surgical pathology"
DOI: 10.1177/10668969211054102
Abstract: Short telomere syndrome (STS) encompasses a broad family of genetically inherited conditions caused by various mutations in telomerase and other telomere maintenance genes, resulting in premature telomere shortening. STS involves a variety of clinical manifestations,… read more here.
Keywords: liver; report; telomere syndrome; short telomere ... See more keywords