Short Telomeres Induce p53 and Autophagy and Modulate Age‐Associated Changes in Cardiac Progenitor Cell Fate
Sign Up to like & getrecommendations! Published in 2018 at "STEM CELLS"
DOI: 10.1002/stem.2793
Abstract: Aging severely limits myocardial repair and regeneration. Delineating the impact of age‐associated factors such as short telomeres is critical to enhance the regenerative potential of cardiac progenitor cells (CPCs). We hypothesized that short telomeres activate… read more here.
Keywords: cell fate; age associated; short telomeres;
Structural modeling of a novel TERC variant in a patient with aplastic anemia and short telomeres
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Hematology"
DOI: 10.1007/s00277-018-3415-5
Abstract: Dear Editor, Inherited bone marrow failure syndromes (IBMFS) are a heterogeneous group of genetic blood disorders in which there is usually some form of aplastic anemia, associatedwith a family history of the same disorder. In… read more here.
Keywords: aplastic anemia; anemia; terc variant; terc ... See more keywords
Rnr1’s role in telomere elongation cannot be replaced by Rnr3: a role beyond dNTPs?
Sign Up to like & getrecommendations! Published in 2017 at "Current Genetics"
DOI: 10.1007/s00294-017-0779-3
Abstract: Telomeres, the nucleoprotein complexes at the end of eukaryotic chromosomes, protect them from degradation and ensure the replicative capacity of cells. In most human tumors and in budding yeast, telomere length is maintained by the… read more here.
Keywords: role telomere; elongation; role; short telomeres ... See more keywords
Short telomeres and severe COVID-19: The connection conundrum
Sign Up to like & getrecommendations! Published in 2021 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2021.103513
Abstract: The exponential rise of COVID-19 mortality among older adults has been rightly attributed to a declining immunity with age. Still, for unknown reasons, older adults are far more likely to die from COVID-19 than from… read more here.
Keywords: telomeres severe; cell; hematopoietic cell; short telomeres ... See more keywords
Telomere length positively correlates with pace‐of‐life in a sex‐ and cohort‐specific way and elongates with age in a wild mammal
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Ecology"
DOI: 10.1111/mec.16533
Abstract: Understanding ageing and the diversity of life histories is a cornerstone in biology. Telomeres, the protecting caps of chromosomes, are thought to be involved in ageing, cancer risks and life‐history strategies. They shorten with cell… read more here.
Keywords: pace life; telomere length; hypothesis; age ... See more keywords
Increase in short telomeres during the third trimester in human placenta
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DOI: 10.1371/journal.pone.0271415
Abstract: An increase in telomere shortening in gestational tissues has been proposed as a mechanism involved in the timing for the initiation of parturition. An increase in very short telomeres with increasing gestational age has been… read more here.
Keywords: increase short; increase; short telomeres; term ... See more keywords
Critically short telomeres and toxicity of chemotherapy in early breast cancer
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DOI: 10.18632/oncotarget.15592
Abstract: Cumulative toxicity from weekly paclitaxel (myalgia, peripheral neuropathy, fatigue) compromises long-term administration. Preclinical data suggest that the burden of critically short telomeres (< 3 kilobases, CSTs), but not average telomere length by itself, accounts for… read more here.
Keywords: breast cancer; toxicity; critically short; average telomere ... See more keywords
Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres
Sign Up to like & getrecommendations! Published in 2018 at "eLife"
DOI: 10.7554/elife.31299
Abstract: Pulmonary fibrosis is a fatal lung disease characterized by fibrotic foci and inflammatory infiltrates. Short telomeres can impair tissue regeneration and are found both in hereditary and sporadic cases. We show here that telomerase expression… read more here.
Keywords: fibrosis; treatment; therapeutic effects; pulmonary fibrosis ... See more keywords