Short TRPM2 prevents the targeting of full-length TRPM2 to the surface transmembrane by hijacking to ER associated degradation.
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DOI: 10.1016/j.bbrc.2019.10.065
Abstract: Membrane proteins are targeted to the surface transmembrane after folding and assembling in the endoplasmic reticulum (ER). Misfolded- and unassembled-proteins are degraded by proteasomes following ubiquitination, termed ER-associated degradation (ERAD). Transient receptor potential melastatin 2… read more here.
Keywords: transmembrane; full length; trpm2; short trpm2 ... See more keywords