Nearly complete deletion of BubR1 causes microcephaly through shortened mitosis and massive cell death.
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DOI: 10.1093/hmg/ddz022
Abstract: BUB-related 1 (BubR1) encoded by Budding Uninhibited by Benzimidazole 1B (BUB1B) is a crucial mitotic checkpoint protein ensuring proper segregation of chromosomes during mitosis. Mutations of BUB1B are responsible for mosaic variegated aneuploidy (MVA), a… read more here.
Keywords: shortened mitosis; mitosis; bubr1; cell death ... See more keywords