Identification of a CE-SDS shoulder peak as disulfide-linked fragments from common CH2 cleavages in IgGs and IgG-like bispecific antibodies
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DOI: 10.1080/19420862.2021.1981806
Abstract: ABSTRACT Fragmentation is a well-characterized degradation pathway of therapeutic antibodies and is usually monitored by capillary electrophoresis–sodium dodecyl sulfate (CE-SDS). Although fragments due to cleavage in CH2 domains linked by intrachain disulfide bonds are common… read more here.
Keywords: ch2; sds; shoulder peak; igg like ... See more keywords