Agonists and Antagonists Show Different Unbinding Paths from the TLR8 Receptor
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.5c00496
Abstract: Toll-like receptors (TLRs) form the first barrier of the innate immune system. TLR8 is an important target to treat autoimmune diseases since its ligand-induced degree of activation regulates immune response and associated hyperinflammation. Molecular dynamics… read more here.
Keywords: receptor; antagonists show; different unbinding; show different ... See more keywords
Global Methylome Scores Correlate with Histological Subtypes of Colorectal Carcinoma and Show Different Associations with Common Clinical and Molecular Features
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13205165
Abstract: Simple Summary Aberrant patterns of methylation at specific genome sequences (CpG) are driving forces for the carcinogenesis process of different cancers, including colorectal cancer (CRC) and, typically, include gene promoter hypermethylation and global genome hypomethylation.… read more here.
Keywords: methylation; histological subtypes; hypermethylation; molecular features ... See more keywords