Piperazine‐Modified Ketoconazole Derivatives Show Increased Activity against Fungal and Trypanosomatid Pathogens
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200385
Abstract: Ketoconazole (KTZ) is an imidazole drug applied topically to treat numerous skin infections. However, as a systemic antifungal, KTZ′ efficacy and safety no longer justify its use as a first‐line treatment. Azole conjugates often display… read more here.
Keywords: piperazine modified; modified ketoconazole; show increased; derivatives show ... See more keywords
Mice lacking L‐12/15‐lipoxygenase show increased mortality during kindling despite demonstrating resistance to epileptogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Epilepsia Open"
DOI: 10.1002/epi4.12221
Abstract: Studies have addressed the potential involvement of L‐12/15‐lipoxygenases (LOs), a polyunsaturated fatty acid metabolizing enzyme, in experimental models of acute stroke and chronic neurodegeneration; however, none to our knowledge has explored its role in epilepsy… read more here.
Keywords: increased mortality; epileptogenesis; show increased; mice lacking ... See more keywords
Human iPSC-derived astrocytes from ALS patients with mutated C9ORF72 show increased oxidative stress and neurotoxicity
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.11.026
Abstract: Background Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects motor neurons (MNs). It was shown that human astrocytes with mutations in genes associated with ALS, like C9orf72 (C9) or SOD1, reduce survival… read more here.
Keywords: oxidative stress; stress; show increased; astrocytes als ... See more keywords
Patients with MS show increased consultations several years before diagnosis
Sign Up to like & getrecommendations! Published in 2017 at "British Medical Journal"
DOI: 10.1136/bmj.j1976
Abstract: Patients with multiple sclerosis (MS) experienced problems that prompted increased consultations with doctors in the five years before having the condition diagnosed, a large study has found. The authors said that the findings may help… read more here.
Keywords: years diagnosis; patients show; several years; consultations several ... See more keywords