Design, synthesis, and biological evaluation of aminopyridine derivatives as novel tropomyosin receptor kinase inhibitors
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DOI: 10.1002/ardp.202200438
Abstract: Tropomyosin receptor kinase (TRK) is a successful target for the treatment of various cancers caused by NTRK gene fusions. Herein, based on a rational drug design strategy, we designed and synthesized 35 aminopyrimidine derivatives that… read more here.
Keywords: tropomyosin receptor; evaluation; receptor kinase; showed compound ... See more keywords