Disulfiram/copper shows potent cytotoxic effects on myelodysplastic syndromes via inducing Bip-mediated apoptosis and suppressing autophagy.
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DOI: 10.1016/j.ejphar.2021.174107
Abstract: Patients with myelodysplastic syndromes (MDS) who resist or fail to respond to hypomethylating agents (HMAs) show very poor outcomes and have no effective treatment strategies. Therefore, new therapeutic approaches are urgently needed for MDS patients… read more here.
Keywords: myelodysplastic syndromes; cytotoxic effects; dsf; shows potent ... See more keywords