Dimensional stabilisation of Scots pine (Pinus sylvestris L.) sapwood by reaction with maleic anhydride and sodium hypophosphite
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Wood and Wood Products"
DOI: 10.1007/s00107-020-01650-6
Abstract: Wood has the ability to absorb and desorb moisture, which can affect its dimensional size when in use. Limiting this can provide products with greater shape stability and less stresses on external coatings. One method… read more here.
Keywords: dimensional stabilisation; maleic anhydride; sodium hypophosphite; scots pine ... See more keywords
Sequential combination of docetaxel with a SHP-1 agonist enhanced suppression of p-STAT3 signaling and apoptosis in triple negative breast cancer cells
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-017-1549-x
Abstract: Triple negative breast cancer (TNBC) is an aggressive cancer for which prognosis remains poor. Combination therapy is a promising strategy for enhancing treatment efficacy. Blockade of STAT3 signaling may enhance the response of cancer cells… read more here.
Keywords: combination; combination docetaxel; stat3; shp ... See more keywords
Geranylnaringenin (CG902) inhibits constitutive and inducible STAT3 activation through the activation of SHP‐2 tyrosine phosphatase
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2017.06.131
Abstract: ABSTRACT The roles and significance of signal transducer and activator of transcription 3 (STAT3) in human cancers have been extensively studied and STAT3 is a promising therapeutic target for cancer drug discovery. During the screening… read more here.
Keywords: cg902; geranylnaringenin cg902; activation; stat3 activation ... See more keywords
Delivery nanosystems based on sterically hindered phenol derivatives containing a quaternary ammonium moiety: Synthesis, cholinesterase inhibition and antioxidant activity.
Sign Up to like & getrecommendations! Published in 2019 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2019.108753
Abstract: Multitarget ligands (MTL) based on sterically hindered phenol and containing a quaternary ammonium moiety (SHP-n-Q) were synthesized. These compounds are inhibitors of cholinesterases with antioxidant properties. The inhibitory selectivity is 10-fold potent for BChE than… read more here.
Keywords: sterically hindered; hindered phenol; containing quaternary; based sterically ... See more keywords
Prion-like Propagation of α-Synuclein Is Regulated by the FcγRIIB-SHP-1/2 Signaling Pathway in Neurons.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2017.12.009
Abstract: Recent evidence of prion-like propagation of α-synuclein (α-syn) into neighboring neurons set up a paradigm to elucidate the mechanism of progression of Parkinson's disease (PD) and to develop therapeutic strategies. Here, we show that FcγRIIB… read more here.
Keywords: prion like; shp signaling; signaling pathway; riib shp ... See more keywords
Stem cell factor and NSC87877 synergism enhances c‐Kit mediated proliferation of human erythroid cells
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.09.055
Abstract: ABSTRACT The biological mechanisms underlying the effects of stem cell factor (SCF) and an inhibitor, NSC87877 (N) of the c‐Kit negative regulator (SHP‐1 and SHP‐2) on cell proliferation are different. Therefore, we compared the cell's… read more here.
Keywords: shp shp; cell factor; proliferation; stem cell ... See more keywords
Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09431-3
Abstract: The phosphatase Shp-2 was implicated in NK cell development and functions due to its interaction with NK inhibitory receptors, but its exact role in NK cells is still unclear. Here we show, using mice conditionally… read more here.
Keywords: critical erk; shp critical; downstream; cell ... See more keywords
Hyperglycaemia-induced methylglyoxal accumulation potentiates VEGF resistance of diabetic monocytes through the aberrant activation of tyrosine phosphatase SHP-2/SRC kinase signalling axis
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-33014-9
Abstract: Diabetes mellitus (DM) is a major cardiovascular risk factor contributing to cardiovascular complications by inducing vascular cell dysfunction. Monocyte dysfunction could contribute to impaired arteriogenesis response in DM patients. DM monocytes show blunted chemotactic responses… read more here.
Keywords: dysfunction; src kinase; vegf resistance; shp src ... See more keywords
Preparation of SiO2 resin coating with superhydrophobic wettability and anti-icing behavior analysis
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra05904e
Abstract: Among different types of anti-icing coatings, superhydrophobic surfaces have attracted extensive attention due to their excellent water repellency and low thermal conductivity. We report facile spraying time tuning to optimize the superhydrophobic (SHP) surface coating… read more here.
Keywords: time; shp; surface; icing behavior ... See more keywords
The effectiveness of small heterodimer partner and FGF 19 levels in prediction of perinatal morbidity in intrahepatic cholestasis of pregnancy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Obstetrics and Gynaecology"
DOI: 10.1080/01443615.2022.2028275
Abstract: Abstract Fibroblast growth factor 19 (FGF19) and small heterodimer partner (SHP) are molecules responsible for controlling serum bile acid levels. We designed this study for evaluating the effects of FGF 19 and SHP in intrahepatic… read more here.
Keywords: shp; serum; pregnancy; fgf ... See more keywords
Src-homology domain 2 containing protein tyrosine phosphatase-1 (SHP-1) directly binds to proto-oncogene tyrosine-protein kinase Src (c-Src) and promotes the transcriptional activation of connexin 43 (Cx43)
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2079252
Abstract: ABSTRACT The prevalence of atrial fibrillation (AF), which is one of the common arrhythmias in clinics, is increasing sharply and has affected millions of patients, which is expected to triple by 2050. The purpose of… read more here.
Keywords: shp; cx43; src homology; activation ... See more keywords