DNA methyltransferase 1 mediated aberrant methylation and silencing of SHP-1 gene in chronic myelogenous leukemia cells.
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DOI: 10.1016/j.leukres.2017.03.014
Abstract: INTRODUCTION Extensive studies on SHP-1 protein and SHP-1 mRNA revealed that the diminishment or abolishment of the expression of SHP-1 in leukemias/lymphomas was due to aberrant promoter methylation. Thus far, the mechanism of epigenetic silencing… read more here.
Keywords: methylation; silencing shp; shp gene; chronic myelogenous ... See more keywords