Exploring the dynamic mechanism of allosteric drug SHP099 inhibiting SHP2E69K
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DOI: 10.1007/s11030-020-10179-y
Abstract: Abstract The E69K mutation is one of the most frequent protein tyrosine phosphatase-2 (SHP2) mutations in leukemia, and it can cause the increase in the protein activity. Recent studies have shown that the E69K mutation… read more here.
Keywords: shp2; drug shp099; shp099 inhibiting; allosteric drug ... See more keywords