SHP1 regulates a STAT6–ITGB3 axis in FLT3ITD-positive AML cells
Sign Up to like & getrecommendations! Published in 2019 at "Leukemia"
DOI: 10.1038/s41375-019-0676-5
Abstract: Acute myeloid leukemia (AML) is a life-threatening disease with limited treatment opportunities. FMS-like tyrosine kinase 3 with internal tandem duplications (FLT3ITD) is a constitutively active receptor tyrosine kinase, found in 25–30% of AML cases and… read more here.
Keywords: shp1 depletion; supplementary fig; disease; shp1 ... See more keywords
THEMIS increases TCR signaling in CD4+CD8+ thymocytes by inhibiting the activity of the tyrosine phosphatase SHP1
Sign Up to like & getrecommendations! Published in 2023 at "Science Signaling"
DOI: 10.1126/scisignal.ade1274
Abstract: The T cell lineage–restricted protein THEMIS plays a critical role in T cell development at the positive selection stage. In the SHP1 activation model, THEMIS is proposed to enhance the activity of the tyrosine phosphatase… read more here.
Keywords: cd4 cd8; themis; tcr signaling; selection ... See more keywords
OP0306 CD11C-SPECIFIC ABLATION OF SHP1 INDUCES AUTOIMMUNE SIALADENITIS SIMILAR TO SJÖGREN’S SYNDROME
Sign Up to like & getrecommendations! Published in 2020 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2020-eular.1044
Abstract: Dendritic cells (DCs) play important roles in inducing immune response as well as maintaining immune tolerance. Src homology 2 domain-containing protein tyrosine phosphatase-1 (Shp1) is a negative regulator of signaling in hematopoietic cells and is… read more here.
Keywords: shp1; none declared; shp1 cko; salivary glands ... See more keywords
Vitamin E Enhances Cancer Immunotherapy by Reinvigorating Dendritic Cells via Targeting Checkpoint SHP1.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-21-0900
Abstract: Despite the popular use of dietary supplements during conventional cancer treatments, their impacts on the efficacies of prevalent immunotherapies, including immune checkpoint therapy (ICT), are unknown. Surprisingly, our analyses of electronic health records revealed that… read more here.
Keywords: shp1; dendritic cells; vitamin enhances; cancer ... See more keywords
Synthesis and Biological Evaluation of 3-Amino-4,4-Dimethyl Lithocholic Acid Derivatives as Novel, Selective, and Cellularly Active Allosteric SHP1 Activators
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28062488
Abstract: Src homology 2 domain-containing protein tyrosine phosphatase 1 (SHP1), a non-receptor member of the protein tyrosine phosphatase (PTP) family, negatively regulates several signaling pathways that are responsible for pathological cell processes in cancers. In this… read more here.
Keywords: shp1 activators; dimethyl lithocholic; amino dimethyl; lithocholic acid ... See more keywords