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   Articles with "shp2" as a keyword



SHP2‐Triggered Endothelial Cell Activation Fuels Estradiol‐Independent Endometrial Sterile Inflammation

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202403038

Abstract: Sterile inflammation occurs in various chronic diseases due to many nonmicrobe factors. Examples include endometrial hyperplasia (EH), endometriosis, endometrial cancer, and breast cancer, which are all sterile inflammation diseases induced by estrogen imbalances. However, how… read more here.

Keywords: activation; cell; shp2; sterile inflammation ... See more keywords

A procedure combining molecular docking and semiempirical method PM7 for identification of selective Shp2 inhibitors.

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recommendations! Published in 2019 at "Biopolymers"

DOI: 10.1002/bip.23320

Abstract: Shp2 and Shp1 make up a small family of protein tyrosine phosphatases. Finding selective inhibitors for Shp2 is useful because although its inhibition is advantageous for the treatment of some types of cancer, inhibition of… read more here.

Keywords: shp2; identification selective; shp2 shp1; interaction ... See more keywords

Shp2 promotes liver cancer stem cell expansion by augmenting β‐catenin signaling and predicts chemotherapeutic response of patients

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recommendations! Published in 2017 at "Hepatology"

DOI: 10.1002/hep.28919

Abstract: Src‐homology 2 domain–containing phosphatase 2 (Shp2) has been reported to play an important role in the maintenance and self‐renewal of embryonic and adult stem cells, but its role in cancer stem cells (CSCs) remains obscure.… read more here.

Keywords: shp2; expansion; catenin; stem ... See more keywords

Overriding adaptive resistance to sorafenib via combination therapy with SHP2 blockade in hepatocellular carcinoma.

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recommendations! Published in 2019 at "Hepatology"

DOI: 10.1002/hep.30989

Abstract: The survival benefit of sorafenib for hepatocellular carcinoma (HCC) patients is unsatisfactory due to the development of adaptive resistance. Increasing evidence has demonstrated that drug resistance can be acquired by cancer cells by activating a… read more here.

Keywords: hepatocellular carcinoma; combination; shp2; sorafenib ... See more keywords

Pharmaceutical SH2 domain–containing protein tyrosine phosphatase 2 inhibition suppresses primary and metastasized liver tumors by provoking hepatic innate immunity

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recommendations! Published in 2022 at "Hepatology"

DOI: 10.1002/hep.32555

Abstract: Background and Aims: SH2 domain–containing protein tyrosine phosphatase 2 (Shp2) is the first identified pro‐oncogenic tyrosine phosphatase that acts downstream of receptor tyrosine kinases (RTKs) to promote Ras–extracellular signal–regulated kinase signaling. However, this phosphatase was… read more here.

Keywords: inhibition; shp2; phosphatase; metastasized liver ... See more keywords

The gain‐of‐function mutation E76K in SHP2 promotes CAC tumorigenesis and induces EMT via the Wnt/β‐catenin signaling pathway

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recommendations! Published in 2018 at "Molecular Carcinogenesis"

DOI: 10.1002/mc.22785

Abstract: SHP2 is encoded by the protein tyrosine phosphatase 11 (Ptpn11) gene. Several gain‐of‐function (GOF) mutations in Ptpn11 have been identified in human hematopoietic malignancies and solid tumors. In addition, the mutation rate for SHP2 is… read more here.

Keywords: shp2; wnt catenin; mutation; crc ... See more keywords

Discovery of a novel SHP2 allosteric inhibitor using virtual screening, FMO calculation, and molecular dynamic simulation

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recommendations! Published in 2024 at "Journal of Molecular Modeling"

DOI: 10.1007/s00894-024-05935-y

Abstract: SHP2 is a non-receptor protein tyrosine phosphatase to remove tyrosine phosphorylation. Functionally, SHP2 is an essential bridge to connect numerous oncogenic cell-signaling cascades including RAS-ERK, PI3K-AKT, JAK-STAT, and PD-1/PD-L1 pathways. This study aims to discover… read more here.

Keywords: simulation; shp2; virtual screening; allosteric inhibitor ... See more keywords

Exploring the dynamic mechanism of allosteric drug SHP099 inhibiting SHP2E69K

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recommendations! Published in 2021 at "Molecular Diversity"

DOI: 10.1007/s11030-020-10179-y

Abstract: Abstract The E69K mutation is one of the most frequent protein tyrosine phosphatase-2 (SHP2) mutations in leukemia, and it can cause the increase in the protein activity. Recent studies have shown that the E69K mutation… read more here.

Keywords: shp2; drug shp099; shp099 inhibiting; allosteric drug ... See more keywords

The tyrosine phosphatase SHP2 promotes proliferation and oxaliplatin resistance of colon cancer cells through AKT and ERK.

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recommendations! Published in 2021 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2021.05.068

Abstract: The SH2 domain-containing phosphatase 2 (SHP2) is a widely expressed protein tyrosine phosphatase, and it is proposed to act as an oncogenic protein. SHP2 is also engaged in drug resistance of a variety of cancers.… read more here.

Keywords: shp2; akt erk; proliferation; resistance ... See more keywords

Design, synthesis and biological evaluation of pyridine derivatives as selective SHP2 inhibitors.

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recommendations! Published in 2020 at "Bioorganic chemistry"

DOI: 10.1016/j.bioorg.2020.103875

Abstract: SHP2 is a non-receptor protein tyrosine phosphatase encoded by the PTPN11 gene, which affects the transduction of multiple signaling pathways, including RAS-ERK, PI3K-AKT and JAK-STAT. SHP2 also plays an important role in the programmed cell… read more here.

Keywords: selective shp2; shp2; shp2 inhibitors; activity ... See more keywords

A shift in the IL-6/STAT3 signalling pathway imbalance towards the SHP2 pathway in severe asthma results in reduced proliferation process.

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recommendations! Published in 2018 at "Cellular signalling"

DOI: 10.1016/j.cellsig.2017.12.001

Abstract: BACKGROUND Bronchial fibroblasts are the main structural cells responsible for extracellular matrix production and turnover in lung tissue. They play a key role in airway remodelling in asthma through different cytokines including interleukin (IL-6). OBJECTIVE… read more here.

Keywords: shp2; healthy controls; severe asthma; proliferation ... See more keywords