A procedure combining molecular docking and semiempirical method PM7 for identification of selective Shp2 inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "Biopolymers"
DOI: 10.1002/bip.23320
Abstract: Shp2 and Shp1 make up a small family of protein tyrosine phosphatases. Finding selective inhibitors for Shp2 is useful because although its inhibition is advantageous for the treatment of some types of cancer, inhibition of… read more here.
Keywords: shp2; identification selective; shp2 shp1; interaction ... See more keywords
Shp2 promotes liver cancer stem cell expansion by augmenting β‐catenin signaling and predicts chemotherapeutic response of patients
Sign Up to like & getrecommendations! Published in 2017 at "Hepatology"
DOI: 10.1002/hep.28919
Abstract: Src‐homology 2 domain–containing phosphatase 2 (Shp2) has been reported to play an important role in the maintenance and self‐renewal of embryonic and adult stem cells, but its role in cancer stem cells (CSCs) remains obscure.… read more here.
Keywords: shp2; expansion; catenin; stem ... See more keywords
Overriding adaptive resistance to sorafenib via combination therapy with SHP2 blockade in hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30989
Abstract: The survival benefit of sorafenib for hepatocellular carcinoma (HCC) patients is unsatisfactory due to the development of adaptive resistance. Increasing evidence has demonstrated that drug resistance can be acquired by cancer cells by activating a… read more here.
Keywords: hepatocellular carcinoma; combination; shp2; sorafenib ... See more keywords
Pharmaceutical SH2 domain–containing protein tyrosine phosphatase 2 inhibition suppresses primary and metastasized liver tumors by provoking hepatic innate immunity
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32555
Abstract: Background and Aims: SH2 domain–containing protein tyrosine phosphatase 2 (Shp2) is the first identified pro‐oncogenic tyrosine phosphatase that acts downstream of receptor tyrosine kinases (RTKs) to promote Ras–extracellular signal–regulated kinase signaling. However, this phosphatase was… read more here.
Keywords: inhibition; shp2; phosphatase; metastasized liver ... See more keywords
The gain‐of‐function mutation E76K in SHP2 promotes CAC tumorigenesis and induces EMT via the Wnt/β‐catenin signaling pathway
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22785
Abstract: SHP2 is encoded by the protein tyrosine phosphatase 11 (Ptpn11) gene. Several gain‐of‐function (GOF) mutations in Ptpn11 have been identified in human hematopoietic malignancies and solid tumors. In addition, the mutation rate for SHP2 is… read more here.
Keywords: shp2; wnt catenin; mutation; crc ... See more keywords
Exploring the dynamic mechanism of allosteric drug SHP099 inhibiting SHP2E69K
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Diversity"
DOI: 10.1007/s11030-020-10179-y
Abstract: Abstract The E69K mutation is one of the most frequent protein tyrosine phosphatase-2 (SHP2) mutations in leukemia, and it can cause the increase in the protein activity. Recent studies have shown that the E69K mutation… read more here.
Keywords: shp2; drug shp099; shp099 inhibiting; allosteric drug ... See more keywords
The tyrosine phosphatase SHP2 promotes proliferation and oxaliplatin resistance of colon cancer cells through AKT and ERK.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.05.068
Abstract: The SH2 domain-containing phosphatase 2 (SHP2) is a widely expressed protein tyrosine phosphatase, and it is proposed to act as an oncogenic protein. SHP2 is also engaged in drug resistance of a variety of cancers.… read more here.
Keywords: shp2; akt erk; proliferation; resistance ... See more keywords
Design, synthesis and biological evaluation of pyridine derivatives as selective SHP2 inhibitors.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.103875
Abstract: SHP2 is a non-receptor protein tyrosine phosphatase encoded by the PTPN11 gene, which affects the transduction of multiple signaling pathways, including RAS-ERK, PI3K-AKT and JAK-STAT. SHP2 also plays an important role in the programmed cell… read more here.
Keywords: selective shp2; shp2; shp2 inhibitors; activity ... See more keywords
A shift in the IL-6/STAT3 signalling pathway imbalance towards the SHP2 pathway in severe asthma results in reduced proliferation process.
Sign Up to like & getrecommendations! Published in 2018 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2017.12.001
Abstract: BACKGROUND Bronchial fibroblasts are the main structural cells responsible for extracellular matrix production and turnover in lung tissue. They play a key role in airway remodelling in asthma through different cytokines including interleukin (IL-6). OBJECTIVE… read more here.
Keywords: shp2; healthy controls; severe asthma; proliferation ... See more keywords
A new abietane diterpenoid from Ajuga ovalifolia var. calantha induces human lung epithelial A549 cell apoptosis by inhibiting SHP2.
Sign Up to like & getrecommendations! Published in 2020 at "Fitoterapia"
DOI: 10.1016/j.fitote.2020.104484
Abstract: The Src-homology 2 domain-containing phosphatase 2 (SHP2), encoded by PTPN11, has been reported oncogenic tyrosine phosphatase associated with various tumors and played critical roles in many cell signaling events. Targeting SHP2 by small molecules may… read more here.
Keywords: shp2; ajuga ovalifolia; abietane diterpenoid; var calantha ... See more keywords
Expression of protein tyrosine phosphatases and Bombyx embryonic development.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of insect physiology"
DOI: 10.1016/j.jinsphys.2021.104198
Abstract: Protein phosphorylation is an integral component of signal transduction pathways within eukaryotic cells, and it is regulated by coordinated interactions between protein kinases and protein phosphatases. Our previous study demonstrated differential expressions of serine/threonine protein… read more here.
Keywords: protein; shp2; embryonic development; diapause eggs ... See more keywords