A procedure combining molecular docking and semiempirical method PM7 for identification of selective Shp2 inhibitors.
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DOI: 10.1002/bip.23320
Abstract: Shp2 and Shp1 make up a small family of protein tyrosine phosphatases. Finding selective inhibitors for Shp2 is useful because although its inhibition is advantageous for the treatment of some types of cancer, inhibition of… read more here.
Keywords: shp2; identification selective; shp2 shp1; interaction ... See more keywords