LncRNA SNHG1 promotes &agr;‐synuclein aggregation and toxicity by targeting miR‐15b‐5p to activate SIAH1 in human neuroblastoma SH‐SY5Y cells
Sign Up to like & getrecommendations! Published in 2018 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2017.12.001
Abstract: HighlightsSNHG1 is upregulated and miR‐15b‐5p is downregulated in PD.SIAH1 promotes &agr;‐synuclein aggregation and toxicity.SIAH1 is a target gene of miR‐15b‐5p.SNHG1 is able to directly bind to miR‐15‐5p and represses miR‐15‐5p expression.SNHG1 promotes &agr;‐synuclein aggregation and… read more here.
Keywords: synuclein aggregation; snhg1; mir 15b; siah1 ... See more keywords
FRK inhibits glioblastoma progression via phosphorylating YAP and inducing its ubiquitylation and degradation by Siah1
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DOI: 10.1093/neuonc/noac156
Abstract: Abstract Background We previously report that yes-associated protein (YAP), the core downstream effector of Hippo pathway, promotes the malignant progression of glioblastoma (GBM). However, although classical regulatory mechanisms of YAP are well explored, how YAP… read more here.
Keywords: siah1; progression; yap inducing; frk ... See more keywords