Aggregation‐Induced Emission (AIE) Photosensitizer Combined Polydopamine Nanomaterials for Organelle‐Targeting Photodynamic and Photothermal Therapy by the Recognition of Sialic Acid
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202200242
Abstract: The construction of organelle‐targeting nanomaterials is an effective way to improve tumor imaging and treatment. Here, a new type of composite nanomaterial named as PTTPB is developed. PTTPB is composed of organelle‐targeting aggregation‐induced emission photosensitizer… read more here.
Keywords: induced emission; therapy; aggregation induced; organelle targeting ... See more keywords
Recombinant Snail Sialic Acid Aldolase is Promiscuous towards Aliphatic Aldehydes
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200074
Abstract: Aldolases are enzymes that reversibly catalyze the cleavage of carbon‐carbon bonds. Here we describe a recombinant sialic acid aldolase originating from the freshwater snail Biomphalaria glabrata (sNPL), and compare its substrate spectrum with a sialic… read more here.
Keywords: sialic acid; acid aldolase; recombinant snail; snpl ... See more keywords
Sialic Acid 4‐N‐Piperazine and Piperidine Derivatives Bind with High Affinity to the P. mirabilis Sialic Acid Sodium Solute Symporter
Sign Up to like & getrecommendations! Published in 2022 at "Chemmedchem"
DOI: 10.1002/cmdc.202200351
Abstract: In search for novel antibacterial compounds, bacterial sialic acid uptake inhibition represents a promising strategy. Sialic acid plays a critical role for growth and colonisation of several pathogenic bacteria, and its uptake inhibition in bacteria… read more here.
Keywords: sialic acid; sodium solute; affinity mirabilis;
Serum Total Sialic Acid Level is Elevated in Hypothyroid Patients as an Atherosclerotic Risk Factor
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.22034
Abstract: Serum total sialic acid (TSA) concentration is regarded as an indicator of the risks of atherosclerosis and cardiovascular diseases. The association between SA levels and atherosclerosis risk factors has not been assessed in patients with… read more here.
Keywords: risk; serum total; total sialic; acid level ... See more keywords
On-tissue amidation of sialic acid with aniline for sensitive imaging of sialylated N-glycans from FFPE tissue sections via MALDI mass spectrometry
Sign Up to like & getrecommendations! Published in 2022 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-022-03894-y
Abstract: Spatial visualization of glycans within clinical tissue samples is critical for discovery of disease-relevant glycan dysregulations. Herein, we develop an on-tissue derivatization strategy for sensitive spatial visualization of N-glycans from formalin-fixed paraffin-embedded (FFPE) tissue sections,… read more here.
Keywords: tissue sections; tissue; sialic acid; amidation ... See more keywords
α2,6-linked sialic acid serves as a high-affinity receptor for cancer oncolytic virotherapy with Newcastle disease virus
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-017-2470-y
Abstract: PurposeNewcastle disease virus (NDV) has been applied to oncolytic virotherapy for decades due to its naturally oncolytic property. In spite of the substantiation of the sialic acid receptors of NDV on host cells, knowledge of… read more here.
Keywords: receptor; oncolytic virotherapy; sialic acid; affinity ... See more keywords
Chemical glycomics enrichment: imaging the recycling of sialic acid in living cells
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Inherited Metabolic Disease"
DOI: 10.1007/s10545-017-0118-3
Abstract: The development of metabolic oligosaccharide engineering (MOE) over the past two decades enabled the bioimaging studies of glycosylation processes in physio-pathological contexts. Herein, we successfully applied the chemical reporter strategy to image the fate of… read more here.
Keywords: recycling sialic; glycomics enrichment; enrichment imaging; chemical glycomics ... See more keywords
Targeted versus untargeted omics — the CAFSA story
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DOI: 10.1007/s10545-017-0134-3
Abstract: BackgroundIn 2009, untargeted metabolomics led to the delineation of a new clinico-biological entity called cerebellar ataxia with elevated cerebrospinal free sialic acid, or CAFSA. In order to elucidate CAFSA, we applied sequentially targeted and untargeted… read more here.
Keywords: versus untargeted; cafsa patients; cafsa; free sialic ... See more keywords
MALDI-TOF mass spectrometry imaging for N-glycans on FFPE tissue sections of mouse NASH liver through Sialic acid Benzylamidation.
Sign Up to like & getrecommendations! Published in 2021 at "Glycoconjugate journal"
DOI: 10.1007/s10719-021-09984-w
Abstract: Glycans play an important physiological role and are drawing attention as biomarkers that capture pathophysiological changes. Glycans can be detected by mass spectrometry, but recently matrix-assisted laser desorption/ionization- mass spectrometry imaging (MALDI-MSI) has enabled the… read more here.
Keywords: mass spectrometry; benzylamidation; mass; spectrometry imaging ... See more keywords
Tissue specific expression of sialic acid metabolic pathway: role in GNE myopathy
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Muscle Research and Cell Motility"
DOI: 10.1007/s10974-020-09590-7
Abstract: GNE myopathy is an adult-onset degenerative muscle disease that leads to extreme disability in patients. Biallelic mutations in the rate-limiting enzyme UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine-kinase (GNE) of sialic acid (SA) biosynthetic pathway, was shown to be the cause… read more here.
Keywords: muscle; gne myopathy; tissue; expression ... See more keywords
Sialic acid and iron content in breastmilk of Chinese lactating women
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DOI: 10.1007/s13312-017-1206-z
Abstract: ObjectiveTo study sialic acid and iron content in breastmilk in Chinese women during different lactation stages.MethodsSialic acid and iron content of colostrum, transitional milk, mature milk, and involutional milk were determined using a neuraminidase assay… read more here.
Keywords: milk; acid iron; iron content; iron ... See more keywords