Determination of Major Sialic Acids in Dairy Products by Electrophoretic Stacking Technology with Contactless Conductivity Detection
Sign Up to like & getrecommendations! Published in 2017 at "Food Analytical Methods"
DOI: 10.1007/s12161-017-1082-0
Abstract: Synergistic stacking technique by combining field-amplified sample injection with moving chemical reaction boundary was developed for the sensitive determination of two major sialic acids, N-acetylneuraminic acid (NANA) and N-glycolylneuraminic acid (NGNA) based on capillary electrophoresis… read more here.
Keywords: sialic acids; conductivity detection; contactless conductivity; dairy products ... See more keywords
Presence of sialic acids in bronchioloalveolar cells and identification and quantification of N-acetylneuraminic and N-glycolylneuraminic acids in the lung.
Sign Up to like & getrecommendations! Published in 2019 at "Acta histochemica"
DOI: 10.1016/j.acthis.2019.06.004
Abstract: The lung, in air-breathing vertebrates, is a tree-like structure composed of branching tubes ending in alveoli and lined by diverse and highly specialized epithelial cells. A dense array of complex and diverse glycoconjugates is present… read more here.
Keywords: sialic acids; presence sialic; bronchioloalveolar cells; quantification ... See more keywords
Development of BODIPY labelled sialic acids as sialyltransferase substrates for direct detection of terminal galactose on N- and O-linked glycans.
Sign Up to like & getrecommendations! Published in 2021 at "Carbohydrate research"
DOI: 10.1016/j.carres.2021.108249
Abstract: Glycans on proteins and cell surfaces are useful biomarkers for determining functional interactions with glycan binding proteins, potential disease states, or indeed level of differentiation. The ability to rapidly and sensitively detect or tag specific… read more here.
Keywords: labelled sialic; development bodipy; bodipy labelled; sialic acids ... See more keywords
Selective Inhibition of Sialic Acid-Based Molecular Mimicry in Haemophilus influenzae Abrogates Serum Resistance.
Sign Up to like & getrecommendations! Published in 2018 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2018.05.018
Abstract: Pathogens such as non-typeable Haemophilus influenzae (NTHi) evade the immune system by presenting host-derived sialic acids. NTHi cannot synthesize sialic acids and therefore needs to utilize sialic acids originating from host tissue. Here we report… read more here.
Keywords: acid based; haemophilus influenzae; sialic acids; sialic acid ... See more keywords
Glycocalyx sialic acids regulate Nrf2-mediated signaling by fluid shear stress in human endothelial cells
Sign Up to like & getrecommendations! Published in 2020 at "Redox Biology"
DOI: 10.1016/j.redox.2020.101816
Abstract: Activation of the nuclear factor erythroid 2–related factor 2 (Nrf2) pathway is critical for vascular endothelial redox homeostasis in regions of high, unidirectional shear stress (USS), however the underlying mechanosensitive mediators are not fully understood.… read more here.
Keywords: sialic acids; sia; human endothelial; shear stress ... See more keywords
Precision Characterization of Site-Specific O-Acetylated Sialic Acids on N-Glycoproteins.
Sign Up to like & getrecommendations! Published in 2023 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c04358
Abstract: O-Acetylation is a common modification of sialic acid, playing a significant role in glycoprotein stability, immune response, and cell development. Due to the lack of efficient methods for direct analysis of O-acetylated sialoglycopeptides (O-AcSGPs), the… read more here.
Keywords: characterization site; precision characterization; acetylated sialic; sialic acids ... See more keywords
O-Acetyl Migration within the Sialic Acid Side Chain: A Mechanistic Study Using the Ab Initio Nanoreactor.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00343
Abstract: Many disease-causing viruses target sialic acids on the surface of host cells. Some viruses bind preferentially to sialic acids with O-acetyl modification at the hydroxyl group of C7, C8, or C9 on the glycerol-like side… read more here.
Keywords: side chain; sialic acids; group; migration ... See more keywords
Quantitation of Sialic Acids in Infant Formulas by Liquid Chromatography-Mass Spectrometry: An Assessment of Different Protein Sources and Discovery of New Analogues.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.8b01042
Abstract: Glycosidically bound, but not free, dietary sialic acids are used for the biosynthesis of new glycoconjugates in humans, making the quantitation of these two forms in infant food sources important, as in neonates the demand… read more here.
Keywords: protein; mass spectrometry; sialic acids; infant formulas ... See more keywords
Chemoenzymatic Total Synthesis of Haemophilus ducreyi Lipooligosaccharide Core Octasaccharides Containing Natural and Unnatural Sialic Acids.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00657
Abstract: The first total synthesis of Haemophilus ducreyi lipooligosaccharide core octasaccharides containing natural and unnatural sialic acids has been achieved by an efficient chemoenzymatic approach. A highly convergent [3 + 3] coupling strategy was developed to… read more here.
Keywords: lipooligosaccharide core; sialic acids; ducreyi lipooligosaccharide; total synthesis ... See more keywords
SARS-CoV-2 Spike N-Terminal Domain Engages 9-O-Acetylated α2–8-Linked Sialic Acids
Sign Up to like & getrecommendations! Published in 2023 at "ACS Chemical Biology"
DOI: 10.1021/acschembio.3c00066
Abstract: SARS-CoV-2 viruses engage ACE2 as a functional receptor with their spike protein. The S1 domain of the spike protein contains a C-terminal receptor binding domain (RBD) and an N-terminal domain (NTD). The NTD of other… read more here.
Keywords: binding; sialic acids; terminal domain; domain ... See more keywords
A Chemical Biology Solution to Problems with Studying Biologically Important but Unstable 9-O-Acetyl Sialic Acids.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.6b00928
Abstract: 9-O-Acetylation is a common natural modification on sialic acids (Sias) that terminate many vertebrate glycan chains. This ester group has striking effects on many biological phenomena, including microbe-host interactions, complement action, regulation of immune responses,… read more here.
Keywords: acetyl; chemical biology; sialic acids; group ... See more keywords