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   Articles with "sialidase" as a keyword



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Live Imaging of Virus-Infected Cells by Using a Sialidase Fluorogenic Probe.

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recommendations! Published in 2021 at "Methods in molecular biology"

DOI: 10.1007/978-1-0716-1258-3_13

Abstract: Visualization of virus-infected cells is usually performed by immunostaining with an antiviral antibody. On the other hand, we established an easy method for fluorescence (FL) imaging of cells infected with influenza A and B viruses… read more here.

Keywords: probe; using sialidase; virus infected; sialidase ... See more keywords
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Distribution of a novel enzyme of sialidase family among native filamentous fungi.

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recommendations! Published in 2021 at "Fungal biology"

DOI: 10.1016/j.funbio.2020.12.006

Abstract: Sialidases (neuraminidases, EC 3.2.1.18) are widely distributed in biological systems but there are only scarce data on its production by filamentous fungi. The aim of this study was to obtain information about sialidase distribution in… read more here.

Keywords: enzyme sialidase; distribution novel; filamentous fungi; novel enzyme ... See more keywords
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Intraplantar injection of sialidase reduces mechanical allodynia during inflammatory pain.

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recommendations! Published in 2017 at "Journal of pharmacological sciences"

DOI: 10.1016/j.jphs.2016.10.008

Abstract: Sialic acids are highly charged glycoresidues that are attached to glycoproteins or glycosphingolipids, and they are associated with various biological functions. Gangliosides, sialic acid-containing glycosphingolipids, are abundant in neural tissues and play important roles in… read more here.

Keywords: injection sialidase; intraplantar injection; mechanical allodynia; sialidase ... See more keywords
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Sialidase Inhibitors with Different Mechanisms

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recommendations! Published in 2022 at "Journal of Medicinal Chemistry"

DOI: 10.1021/acs.jmedchem.2c01258

Abstract: Sialidases, or neuraminidases, are enzymes that catalyze the hydrolysis of sialic acid (Sia)-containing molecules, mostly removal of the terminal Sia (desialylation). By desialylation, sialidase can modulate the functionality of the target compound and is thus… read more here.

Keywords: analogue inhibitors; inhibitors different; product; sialidase ... See more keywords
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Desialylation of Atg5 by sialidase (Neu2) enhances autophagosome formation to induce anchorage-dependent cell death in ovarian cancer cells

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recommendations! Published in 2021 at "Cell Death Discovery"

DOI: 10.1038/s41420-020-00391-y

Abstract: Increased sialylation is one of the hallmarks of ovarian cancer (OC) but its relation with programmed cell death is not known. Here we explored the molecular interplay between autophagy, apoptosis/anoikis, and aberrant-expression of the PI3K-Akt/mTOR… read more here.

Keywords: sialidase; cell; autophagosome formation; cell death ... See more keywords
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Sialidase inhibitors attenuate pulmonary fibrosis in a mouse model

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-15198-8

Abstract: Fibrosis involves increasing amounts of scar tissue appearing in a tissue, but what drives this is unclear. In fibrotic lesions in human and mouse lungs, we found extensive desialylation of glycoconjugates, and upregulation of sialidases.… read more here.

Keywords: fibrosis; sialidase inhibitors; sialidase; pulmonary fibrosis ... See more keywords
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Acute stress-induced change in polysialic acid levels mediated by sialidase in mouse brain

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recommendations! Published in 2019 at "Scientific Reports"

DOI: 10.1038/s41598-019-46240-6

Abstract: Stress is an important environmental factor influencing human behaviour and causing several mental disorders. Alterations in the structure of polysialic acid (polySia/PSA) due to genetic alterations in ST8SIA2, which encodes a polySia-synthesizing enzyme, are related… read more here.

Keywords: polysialic acid; acute stress; stress; brain ... See more keywords
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NanJ Is the Major Sialidase for Clostridium perfringens Type F Food Poisoning Strain 01E809

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recommendations! Published in 2023 at "Infection and Immunity"

DOI: 10.1128/iai.00053-23

Abstract: Clostridium perfringens type F strains cause food poisoning (FP) when they sporulate and produce C. perfringens enterotoxin (CPE) in the intestines. Most type F FP strains carry a chromosomal cpe gene (c-cpe strains). C. perfringens… read more here.

Keywords: food poisoning; cpe; strains carry; clostridium perfringens ... See more keywords
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Vibrio cholerae Sialidase-Specific Immune Responses Are Associated with Protection against Cholera

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recommendations! Published in 2021 at "mSphere"

DOI: 10.1128/msphere.01232-20

Abstract: Cholera infection can result in severe dehydration that may lead to death within a short period of time if not treated immediately. Vaccination is an important strategy to prevent the disease. ABSTRACT Cholera remains a… read more here.

Keywords: protection; cholera; vibrio cholerae; infection ... See more keywords
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Abstract CT034: GLIMMER-01: initial results from a phase 1 dose escalation trial of a first-in-class bi-sialidase (E-602) in solid tumors

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recommendations! Published in 2023 at "Cancer Research"

DOI: 10.1158/1538-7445.am2023-ct034

Abstract: Background: Hypersialylation (excessive sialoglycans) on tumor cells has been known to be associated with poorer cancer outcomes for more than 40 years. Sialoglycans are immune suppressive and promote tumor immune evasion by binding to sialoglycan… read more here.

Keywords: first class; solid tumors; dose escalation; sialidase ... See more keywords
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Sialidase Activity in the Cervicovaginal Fluid Is Associated With Changes in Bacterial Components of Lactobacillus-Deprived Microbiota

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recommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"

DOI: 10.3389/fcimb.2021.813520

Abstract: Introduction Sialidase activity in the cervicovaginal fluid (CVF) is associated with microscopic findings of bacterial vaginosis (BV). Sequencing of bacterial 16S rRNA gene in vaginal samples has revealed that the majority of microscopic BV cases… read more here.

Keywords: sialidase activity; changes bacterial; bacterial components; associated changes ... See more keywords