Sialidase Inhibitors with Different Mechanisms
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DOI: 10.1021/acs.jmedchem.2c01258
Abstract: Sialidases, or neuraminidases, are enzymes that catalyze the hydrolysis of sialic acid (Sia)-containing molecules, mostly removal of the terminal Sia (desialylation). By desialylation, sialidase can modulate the functionality of the target compound and is thus… read more here.
Keywords: analogue inhibitors; inhibitors different; product; sialidase ... See more keywords
Sialidase inhibitors attenuate pulmonary fibrosis in a mouse model
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DOI: 10.1038/s41598-017-15198-8
Abstract: Fibrosis involves increasing amounts of scar tissue appearing in a tissue, but what drives this is unclear. In fibrotic lesions in human and mouse lungs, we found extensive desialylation of glycoconjugates, and upregulation of sialidases.… read more here.
Keywords: fibrosis; sialidase inhibitors; sialidase; pulmonary fibrosis ... See more keywords