Synthesis of Bisboronic Acids and Their Selective Recognition of Sialyl Lewis X Antigen
Sign Up to like & getrecommendations! Published in 2018 at "Chemical Research in Chinese Universities"
DOI: 10.1007/s40242-018-7328-6
Abstract: The development of sensors that recognize Lewis oligosaccharides can help the diagnosis and early detection of cancer. Herein, we reported the design and synthesis of a series of anthracene-based bisboronic acids (9a—9e) with different N-substituents… read more here.
Keywords: acids selective; synthesis bisboronic; sialyl lewis; selective recognition ... See more keywords
Targeting epithelial expressed Sialyl Lewis glycans improves colonic mucosal wound healing and protects against colitis.
Sign Up to like & getrecommendations! Published in 2020 at "JCI insight"
DOI: 10.1172/jci.insight.135843
Abstract: Dysregulated healing of injured mucosa is a hallmark of many pathological conditions including inflammatory bowel disease. Mucosal injury and chronic inflammation including persistent neutrophil (PMN) infiltration are also associated with alterations in epithelial glycosylation. Previous… read more here.
Keywords: wound healing; sialyl lewis; lewis glycans; mucosal ... See more keywords
Identification of Sialyl-Lewis(x)-Interacting Protein on Human Spermatozoa
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DOI: 10.3389/fcell.2021.700396
Abstract: Capacitated spermatozoa initiate fertilization by binding to the zona pellucida (ZP). Defective spermatozoa-ZP binding causes infertility. The sialyl-Lewis(x) (SLeX) sequence is the most abundant terminal sequence on the glycans of human ZP glycoproteins involving in… read more here.
Keywords: capacitated spermatozoa; fertilization; sialyl lewis; spermatozoa ... See more keywords
Expression of the Carbohydrate Lewis Antigen, Sialyl Lewis A, Sialyl Lewis X, Lewis X, and Lewis Y in the Placental Villi of Patients With Unexplained Miscarriages
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.679424
Abstract: Background Lewis antigens such as Sialyl Lewis A (sLeA), Sialyl Lewis X (sLeX), Lewis X (LeX), and Lewis Y (LeY) are a class of carbohydrate molecules that are known to mediate adhesion between tumor cells… read more here.
Keywords: sialyl lewis; lewis; miscarriage; expression ... See more keywords
Selectin Ligands Sialyl-Lewis a and Sialyl-Lewis x in Gastrointestinal Cancers
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DOI: 10.3390/biology6010016
Abstract: The tetrasaccharide structures Siaα2,3Galβ1,3(Fucα1,4)GlcNAc and Siaα2,3Galβ1,4(Fucα1,3)GlcNAc constitute the epitopes of the carbohydrate antigens sialyl-Lewis a (sLea) and sialyl-Lewis x (sLex), respectively, and are the minimal requirement for selectin binding to their counter-receptors. Interaction of sLex… read more here.
Keywords: sialyl lewis; selectin ligands; gastrointestinal cancers; cancer ... See more keywords