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   Articles with "sialylation" as a keyword



Boosting Tumor Accumulation of Phthalocyanine through Sialylation Engineering for Superior Cancer Phototherapy

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recommendations! Published in 2024 at "Advanced Healthcare Materials"

DOI: 10.1002/adhm.202402381

Abstract: Phthalocyanines (Pcs) are widely developed in cancer phototherapy due to their definite chemical structure and tunable photosensitivity. However, their in vivo application is hampered by low water solubility and non‐specific biodistribution. Here,a strategy of sialylation‐modulation… read more here.

Keywords: cancer phototherapy; sialylation engineering; tumor; znpc 4sa ... See more keywords

Transient CHO expression platform for robust antibody production and its enhanced N‐glycan sialylation on therapeutic glycoproteins

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recommendations! Published in 2019 at "Biotechnology Progress"

DOI: 10.1002/btpr.2724

Abstract: Large‐scale transient expression in mammalian cells is a rapid protein production technology often used to shorten overall timelines for biotherapeutics drug discovery. In this study we demonstrate transient expression in a Chinese hamster ovary (CHO)… read more here.

Keywords: cho expression; production; sialylation; therapeutic glycoproteins ... See more keywords

Sialylation Impacts Separation of a Biotherapeutic by Capillary Gel Electrophoresis

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recommendations! Published in 2025 at "ELECTROPHORESIS"

DOI: 10.1002/elps.70006

Abstract: Monitoring of critical quality attributes (CQAs) is essential for the development of biotherapeutics. One example of a CQA is molecular fragmentation, which is often analyzed by capillary gel electrophoresis with sodium dodecyl sulfate (SDS). Sialylation… read more here.

Keywords: sds; gel electrophoresis; electrophoresis; sialylation ... See more keywords

Decreased sialylation elicits complement‐related microglia response and bipolar cell loss in the mouse retina

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recommendations! Published in 2024 at "Glia"

DOI: 10.1002/glia.24613

Abstract: Sialylation plays an important role in self‐recognition, as well as keeping the complement and innate immune systems in check. It is unclear whether the reduced sialylation seen during aging and in mice heterozygous for the… read more here.

Keywords: loss; gne mice; complement related; sialylation ... See more keywords

Enzymatic Sialylation of Synthetic Multivalent Scaffolds: From 3'-Sialyllactose Glycomacromolecules to Novel Neoglycosides.

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recommendations! Published in 2022 at "Macromolecular bioscience"

DOI: 10.1002/mabi.202200358

Abstract: Sialoglycans play a key role in many biological recognition processes and sialylated conjugates of various types have successfully been applied, e.g., as antivirals or in anti-tumor therapy. A key feature for high affinity binding of… read more here.

Keywords: sialylation; enzymatic sialylation; multivalent scaffolds; synthetic multivalent ... See more keywords

Increased Transferrin Sialylation Predicts Phenoconversion in Isolated REM Sleep Behavior Disorder

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recommendations! Published in 2022 at "Movement Disorders"

DOI: 10.1002/mds.28942

Abstract: Sialic acid–protein interactions are involved in regulating central nervous system immunity; therefore, derangements in sialylation could be involved in neurodegeneration. read more here.

Keywords: transferrin sialylation; sialylation; increased transferrin; phenoconversion isolated ... See more keywords

Role of sialylation of N-linked glycans in prion pathogenesis.

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recommendations! Published in 2022 at "Cell and tissue research"

DOI: 10.1007/s00441-022-03584-2

Abstract: Mammalian prion or PrPSc is a proteinaceous infectious agent that consists of a misfolded, self-replicating state of the prion protein or PrPC. PrPC and PrPSc are posttranslationally modified with N-linked glycans, which are sialylated at… read more here.

Keywords: role sialylation; linked glycans; strain; prion ... See more keywords

Terminal α2,6-sialylation of epidermal growth factor receptor modulates antibody therapy response of colorectal cancer cells.

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recommendations! Published in 2021 at "Cellular oncology"

DOI: 10.1007/s13402-021-00606-z

Abstract: BACKGROUND The epidermal growth factor receptor (EGFR) is a key protein involved in cancer development. Monoclonal antibodies targeting EGFR are approved for the treatment of metastatic colorectal cancer (CRC). Despite the beneficial clinical effects observed… read more here.

Keywords: therapy; terminal sialylation; cancer; sialylation ... See more keywords

Sialylation status and mechanical properties of THP-1 macrophages upon LPS stimulation.

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recommendations! Published in 2019 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2019.08.089

Abstract: Cell surface receptors are the key contributors of macrophage function. Most macrophage cell surface receptors are glycoproteins with sialic acids at the terminal of their glycans. It is well recognized that lipopolysaccharide (LPS) induces cell… read more here.

Keywords: sialylation status; macrophages upon; macrophage; sialylation ... See more keywords

Native Ion Mobility-Mass Spectrometry-Enabled Fast Structural Interrogation of Labile Protein Surface Modifications at the Intact Protein Level.

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recommendations! Published in 2022 at "Analytical chemistry"

DOI: 10.1021/acs.analchem.1c04503

Abstract: Protein sialylation has been closely linked to many diseases including Alzheimer's disease (AD). It is also broadly implicated in therapeutics operating in a pattern-dependent (e.g., Neu5Ac vs Neu5Gc) manner. However, how the sialylation pattern affects… read more here.

Keywords: mass spectrometry; sialylation; fast structural; native ion ... See more keywords

α2,6-Sialylation Is Upregulated in Severe COVID-19, Implicating the Complement Cascade

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recommendations! Published in 2022 at "ACS Infectious Diseases"

DOI: 10.1021/acsinfecdis.2c00421

Abstract: Better understanding of the molecular mechanisms underlying COVID-19 severity is desperately needed in current times. Although hyper-inflammation drives severe COVID-19, precise mechanisms triggering this cascade and what role glycosylation might play therein are unknown. Here… read more here.

Keywords: severe covid; sialylation; sialylation upregulated; complement cascade ... See more keywords