Inhibition of poly-LacNAc biosynthesis with release of CMP-Neu5Ac feedback inhibition increases the sialylation of recombinant EPO produced in CHO cells
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DOI: 10.1038/s41598-018-25580-9
Abstract: Sialylation of recombinant therapeutic glycoproteins modulates their pharmacokinetic properties by affecting their in vivo half-life. N-glycan branching on glycoproteins increases the number of potential attachment sites for sialic acid. Here, we introduce a new approach… read more here.
Keywords: cho cells; inhibition; sialylation recombinant; poly lacnac ... See more keywords