Prebiotic fructans have greater impact on luminal microbiology and CD3+ T cells in healthy siblings than patients with Crohn's disease: A pilot study investigating the potential for primary prevention of inflammatory bowel disease.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical nutrition"
DOI: 10.1016/j.clnu.2021.05.033
Abstract: BACKGROUND & AIMS Siblings of people with Crohn's disease (CD) share aspects of the disease phenotype (raised faecal calprotectin, altered microbiota), which are markers of risk for their own development of CD. The aim was… read more here.
Keywords: oligofructose inulin; disease; siblings patients; microbiology ... See more keywords
Replicated evidence that endophenotypic expression of schizophrenia polygenic risk is greater in healthy siblings of patients compared to controls, suggesting gene–environment interaction. The EUGEI study
Sign Up to like & getrecommendations! Published in 2019 at "Psychological Medicine"
DOI: 10.1017/s003329171900196x
Abstract: Abstract Background First-degree relatives of patients with psychotic disorder have higher levels of polygenic risk (PRS) for schizophrenia and higher levels of intermediate phenotypes. Methods We conducted, using two different samples for discovery (n =… read more here.
Keywords: risk; psychotic disorder; polygenic risk; siblings patients ... See more keywords