Association of Kidney Comorbidities and Acute Kidney Failure With Unfavorable Outcomes After COVID-19 in Individuals With the Sickle Cell Trait.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA internal medicine"
DOI: 10.1001/jamainternmed.2022.2141
Abstract: Importance Sickle cell trait (SCT), defined as the presence of 1 hemoglobin beta sickle allele (rs334-T) and 1 normal beta allele, is prevalent in millions of people in the US, particularly in individuals of African… read more here.
Keywords: cell trait; acute kidney; kidney; association ... See more keywords
Severe Maternal Morbidity and Mortality in Sickle Cell Disease in the National Inpatient Sample, 2012-2018
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.54552
Abstract: Key Points Question What are the rates of and risks for severe maternal morbidity (SMM) among birthing people with sickle cell disease (SCD), and what proportion of the increased risk for adverse pregnancy outcomes in… read more here.
Keywords: people scd; deliveries among; severe maternal; maternal morbidity ... See more keywords
Changes in Hydroxyurea Use Among Youths Enrolled in Medicaid With Sickle Cell Anemia After 2014 Revision of Clinical Guidelines.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA network open"
DOI: 10.1001/jamanetworkopen.2023.4584
Abstract: Importance Youths with sickle cell anemia (SCA) are at risk of pain crises, stroke, and early death. Complications can be reduced by the oral disease-modifying medication hydroxyurea, and in 2014, the National Heart, Lung, and… read more here.
Keywords: cell anemia; changes hydroxyurea; use; among youths ... See more keywords
Systematic online academic resources (SOAR) review: Sickle cell disorders
Sign Up to like & getrecommendations! Published in 2022 at "AEM Education and Training"
DOI: 10.1002/aet2.10812
Abstract: Free open‐access medical education (FOAM) resources have become highly utilized resources in emergency medicine education. However, FOAM content often lacks the traditional peer review process, leaving quality assessment to the readers. In this systematic online… read more here.
Keywords: online academic; review; systematic online; soar review ... See more keywords
Acute pain in adolescents and young adults with sickle cell disease: Delayed and increased opioid dosing following transition to adult care
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Hematology"
DOI: 10.1002/ajh.24647
Abstract: The transition from pediatric to adult care is a high risk time for adolescent and young adult (AYA) patients with sickle cell disease (SCD). Management of acute pain is a major point of contact between… read more here.
Keywords: adult; transition; adult care; cell disease ... See more keywords
The role of carbon monoxide and heme oxygenase in the prevention of sickle cell disease vaso‐occlusive crises
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Hematology"
DOI: 10.1002/ajh.24750
Abstract: Sickle Cell Disease (SCD) is a painful, lifelong hemoglobinopathy inherited as a missense point mutation in the hemoglobin (Hb) beta‐globin gene. This disease has significant impact on quality of life and mortality, thus a substantial… read more here.
Keywords: occlusive crises; heme; vaso occlusive; disease ... See more keywords
Losartan for the nephropathy of sickle cell anemia: A phase‐2, multicenter trial
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DOI: 10.1002/ajh.24810
Abstract: Nephropathy is a common and progressive complication of sickle cell anemia (SCA). In SCA mice, we found that hyperangiotensinemia in the absence of hypertension underlies nephropathy, and its downregulation by losartan, an angiotensin‐II‐receptor‐1 blocker, reduced… read more here.
Keywords: trial; losartan nephropathy; losartan; cell anemia ... See more keywords
Circulating cell‐free DNA and ineffective erythropoiesis in nontransfusion‐dependent β‐thalassemia
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Hematology"
DOI: 10.1002/ajh.25248
Abstract: REFERENCES 1. Ma S, Cahalan S, LaMonte G, et al. Common PIEZO1 allele in African populations causes RBC dehydration and attenuates plasmodium infection. Cell. 2018;173(2):443-455. e412. 2. Bartolucci P, Brugnara C, Teixeira-Pinto A, et al.… read more here.
Keywords: cell free; circulating cell; blood; cell ... See more keywords
Treatment of CD19‐positive mixed phenotype acute leukemia with blinatumomab
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DOI: 10.1002/ajh.25317
Abstract: sion rates following hospitalization for pediatric sickle cell crisis at freestanding children's hospitals: risk factors and hospital variation. Pediatr Blood Cancer. 2012;58:61-65. 4. Brodsky MA, Rodeghier M, Sanger M, et al. Risk Factors for 30-Day… read more here.
Keywords: mixed phenotype; cd19 positive; positive mixed; treatment cd19 ... See more keywords
Critical role of C5a in sickle cell disease
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DOI: 10.1002/ajh.25384
Abstract: Innate immune complement activation may contribute to sickle cell disease (SCD) pathogenesis. Ischemia‐reperfusion physiology is a key component of the inflammatory and vaso‐occlusive milieu in SCD and is associated with complement activation. C5a is an… read more here.
Keywords: cell disease; stasis; mice; c5a ... See more keywords
Erythrocyte ATP, a possible therapeutic approach for sickle cell disease
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DOI: 10.1002/ajh.25419
Abstract: This letter presents some suggestions of possible therapies for sickle cell disease that are based on interpretations of presumed effects of different substrates that alter the cellular levels of ATP. A prevailing idea is that… read more here.
Keywords: atp; pyruvate; cell disease; sickle ... See more keywords