Piezo1 activation augments sickling propensity and the adhesive properties of sickle red blood cells in a calcium-dependent manner.
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DOI: 10.1111/bjh.18799
Abstract: Haemoglobin S polymerization in the red blood cells (RBCs) of individuals with sickle cell anaemia (SCA) can cause RBC sickling and cellular alterations. Piezo1 is a mechanosensitive protein that modulates intracellular calcium (Ca2+ ) influx,… read more here.
Keywords: red blood; sickling propensity; blood cells; piezo1 activation ... See more keywords