Neuroinflammatory reactions in sickness behavior induced by bacterial infection: Protective effect of minocycline
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22020
Abstract: The neurological changes elicited by bacterial infection are called sickness behavior. Minocycline (MIN) is neuroprotective with a remarkable brain tissue penetration. MIN was orally administered at a dose 90 mg/kg for 3 days, whereas Escherichia… read more here.
Keywords: sickness behavior; minocycline; bacterial infection; infection ... See more keywords
Characterization of sickness behavior in zebrafish
Sign Up to like & getrecommendations! Published in 2018 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2018.07.004
Abstract: In a previous study we showed a clear relationship between immune system and behavior in zebrafish and we hypothesized that the immune system is capable of inducing behavioral changes. To further investigate this subject and… read more here.
Keywords: sickness behavior; characterization sickness; immune system; behavior zebrafish ... See more keywords
Neuroinflammation disorders exacerbated by environmental stressors.
Sign Up to like & getrecommendations! Published in 2019 at "Metabolism: clinical and experimental"
DOI: 10.1016/j.metabol.2019.153951
Abstract: Neuroinflammation is a condition characterized by the elaboration of proinflammatory mediators within the central nervous system. Neuroinflammation has emerged as a dominant theme in contemporary neuroscience due to its association with neurodegenerative disease states such… read more here.
Keywords: sickness behavior; neuroinflammation disorders; environmental stressors; neuroinflammation ... See more keywords
Fluoxetine and Curcumin Prevent the Alterations in Locomotor and Exploratory Activities and Social Interaction Elicited by Immunoinflammatory Activation in Zebrafish: Involvement of BDNF and Proinflammatory Cytokines.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00475
Abstract: The increase in proinflammatory cytokine expression causes behavioral changes consistent with sickness behavior, and this led to the suggestion that depression might be a psychoneuroimmunological phenomenon. Here, we evaluated the effects of the pretreatment with… read more here.
Keywords: expression; fluoxetine curcumin; bdnf; sickness behavior ... See more keywords
Flavonoid-Rich Fraction of Ocimum gratissimum Attenuates Lipopolysaccharide-Induced Sickness Behavior, Inflammatory and Oxidative Stress in Mice.
Sign Up to like & getrecommendations! Published in 2019 at "Drug research"
DOI: 10.1055/a-0654-5042
Abstract: PURPOSE Ocimum gratissimum L. leaves has been traditionally used for management of febrile illnesses and symptoms typified of sickness behavior. In this work we investigated the modulatory effect of flavonoid-rich fraction of O. gratissimum leaves… read more here.
Keywords: sickness behavior; behavior inflammatory; flavonoid rich; rich fraction ... See more keywords
Dexmedetomidine reduces lipopolysaccharide induced neuroinflammation, sickness behavior, and anhedonia
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0191070
Abstract: Background Peripheral innate immune response may induce sickness behavior through activating microglia, excessive cytokines production, and neuroinflammation. Dexmedetomidine (Dex) has anti-inflammatory effect. We investigated the effects of Dex on lipopolysaccharide (LPS)-induced neuroinflammation and sickness behavior… read more here.
Keywords: sickness behavior; dex; neuroinflammation; induced neuroinflammation ... See more keywords
ADAM Metalloproteinase Domain 17 Regulates Cholestasis-Associated Liver Injury and Sickness Behavior Development in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.779119
Abstract: Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) is a ubiquitously expressed membrane-bound enzyme that mediates shedding of a wide variety of important regulators in inflammation including cytokines and adhesion molecules. Hepatic expression of numerous cytokines… read more here.
Keywords: liver injury; expression; behavior development; adam17 ... See more keywords
Hirsutanol A Attenuates Lipopolysaccharide-Mediated Matrix Metalloproteinase 9 Expression and Cytokines Production and Improves Endotoxemia-Induced Acute Sickness Behavior and Acute Lung Injury
Sign Up to like & getrecommendations! Published in 2019 at "Marine Drugs"
DOI: 10.3390/md17060360
Abstract: Activated human monocytes/macrophages, which increase the levels of matrix metalloproteinases (MMPs) and pro-inflammatory cytokines, are the essential mechanisms for the progression of sepsis. In the present study, we determined the functions and mechanisms of hirsutanolA… read more here.
Keywords: sickness behavior; acute sickness; endotoxemia induced; behavior ... See more keywords