Discovery of a Small Side Cavity in Sphingosine Kinase 2 that Enhances Inhibitor Potency and Selectivity.
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DOI: 10.1021/acs.jmedchem.9b01508
Abstract: The sphingosine-1-phosphate (S1P) signaling pathway is an attractive drug target due to its involvement in immune cell chemotaxis and vascular integrity. The formation of S1P is catalyzed by sphingosine kinase 1 or 2 (SphK1 or… read more here.
Keywords: potency selectivity; sphingosine kinase; inhibitor; potency ... See more keywords