Impaired Clearance From the Brain Increases the Brain Exposure to Metoclopramide in Elderly Subjects
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2052
Abstract: The antiemetic and gastroprokinetic drug metoclopramide is a weak substrate of the blood‐brain barrier (BBB) efflux transporter P‐gp and displays central nervous system (CNS) side effects (i.e., extrapyramidal symptoms and tardive dyskinesia) caused by dopamine… read more here.
Keywords: elderly subjects; 11c metoclopramide; clearance; brain ... See more keywords
Supply‐side effects from public insurance expansions: Evidence from physician labor markets
Sign Up to like & getrecommendations! Published in 2018 at "Health Economics"
DOI: 10.1002/hec.3625
Abstract: Medicaid and the Child Health Insurance Programs (CHIP) are key sources of coverage for U.S. children. Established in 1997, CHIP allocated $40 billion of federal funds across the first 10 years but continued support required reauthorization.… read more here.
Keywords: supply side; insurance; evidence; public insurance ... See more keywords
Paradoxical side effects of bisphosphonates on the skeleton: What do we know and what can we do?
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DOI: 10.1002/jcp.26465
Abstract: Bisphosphonates are considered the most effective drugs for controlling adult and pediatric osteolytic diseases. Although they have been used successfully for many years, several side effects, such as osteonecrosis of the jaw, delayed dental eruption,… read more here.
Keywords: paradoxical side; effects bisphosphonates; bisphosphonates skeleton; skeleton know ... See more keywords
Bacterial l‐asparaginases for cancer therapy: Current knowledge and future perspectives
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DOI: 10.1002/jcp.28563
Abstract: l‐Asparaginases hydrolyzing plasma l‐asparagine and l‐glutamine has attracted tremendous attention in recent years owing to remarkable anticancer properties. This enzyme is efficiently used for acute lymphoblastic leukemia (ALL) and lymphosarcoma and emerged against ALL in… read more here.
Keywords: therapy; bacterial asparaginases; cancer; asparaginase ... See more keywords
Modeling effects of risk and social distance on vaccination choice.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the experimental analysis of behavior"
DOI: 10.1002/jeab.438
Abstract: Despite vaccines' consistently demonstrated effectiveness, vaccination rates remain suboptimal due to vaccine refusal. Low vaccination rates are particularly problematic for individuals who cannot be vaccinated for medical reasons and thus must rely on herd immunity… read more here.
Keywords: social distance; vaccination; modeling effects; side effects ... See more keywords
Pediatric and adolescent COVID‐19 vaccination side effects: A retrospective cohort study of the Iranian teenage group in 2021
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27962
Abstract: To determine the safety and efficacy profile of teenager COVID‐19 vaccination. In this retrospective cohort study, contact numbers of parents of teenagers under 18 years of age referred to a teenager vaccination centers in Tehran‐Iran… read more here.
Keywords: vaccination; side; side effects; covid vaccination ... See more keywords
Oral side effects of COVID‐19 vaccines in 32 European countries: Analysis of EudraVigilance reports
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28771
Abstract: The recent reports of oral side effects (SEs) following COVID‐19 vaccination warrant further investigation into their prevalence, severity, and aetiology. This study was conducted to synthesize the first‐ever population‐level evidence about oral SEs of COVID‐19… read more here.
Keywords: eudravigilance; oral ses; covid vaccines; side effects ... See more keywords
Repurposing approved drugs on the pathway to novel therapies
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DOI: 10.1002/med.21627
Abstract: The time and cost of developing new drugs have led many groups to limit their search for therapeutics to compounds that have previously been approved for human use. Many “repurposed” drugs, such as derivatives of… read more here.
Keywords: pathway novel; drugs pathway; approved drugs; repurposing approved ... See more keywords
Potential biomarkers screening to predict side effects of dexamethasone in different cancers
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DOI: 10.1002/mgg3.1160
Abstract: Excessive or prolonged usage of dexamethasone can cause serious side effects, but few studies reveal the related mechanism. Dexamethasone work differently in blood tumors and solid tumors, and the cause is still obscure. The aims… read more here.
Keywords: effects dexamethasone; potential biomarkers; biomarkers screening; dexamethasone different ... See more keywords
Development and pharmacist‐mediated use of tools for monitoring atypical antipsychotic‐induced side effects related to blood glucose levels
Sign Up to like & getrecommendations! Published in 2018 at "Pharmacoepidemiology and Drug Safety"
DOI: 10.1002/pds.4656
Abstract: Drug side effects often lead to serious outcomes. Administration of second‐generation antipsychotics has resulted in diabetic ketoacidosis and diabetic coma leading to death. Therefore, pharmacists are required to collect information on clinical test values, determine… read more here.
Keywords: pharmacist mediated; development pharmacist; mediated use; use tools ... See more keywords
Recent development in antihyperalgesic effect of phytochemicals: anti-inflammatory and neuro-modulatory actions
Sign Up to like & getrecommendations! Published in 2018 at "Inflammation Research"
DOI: 10.1007/s00011-018-1156-5
Abstract: IntroductionPain is an unpleasant sensation triggered by noxious stimulation. It is one of the most prevalent conditions, limiting productivity and diminishing quality of life. Non steroidal anti inflammatory drugs (NSAIDs) are widely used as pain… read more here.
Keywords: anti inflammatory; antihyperalgesic effect; development antihyperalgesic; recent development ... See more keywords